id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.resourceType.isindependentpub "e7ec8846-6140-439c-8af2-4d8ee9848b2f","fub188/15","Banszerus, Verena L.||Vetter, Valentin M.||Salewsky, Bastian||König, Maximilian||Demuth, Ilja","2020-03-05T07:26:43Z","2020-03-05T07:26:43Z","2019","Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age.","https://refubium.fu-berlin.de/handle/fub188/26835||http://dx.doi.org/10.17169/refubium-26593","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","biomarker of ageing||biological age||aging||telomere length||epigenetic clock||DNA methylation (DNAm) age||DNAm age acceleration||LipidCardio Study||Berlin Aging Study II (BASE-II)","Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort","Wissenschaftlicher Artikel","open access","3032","10.3390/ijms20123032","International Journal of Molecular Sciences","12","MDPI AG","31234328","20","1422-0067","Charité - Universitätsmedizin Berlin","no"