id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pageend,dcterms.bibliographicCitation.pagestart,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.issn,refubium.affiliation,refubium.resourceType.isindependentpub "58d3dce9-555c-425e-8157-ff1d5e65198b","fub188/15","Atanasov, Georgi||Pötner, Charlotte||Aust, Gabriela||Schierle, Katrin||Dietel, Corinna||Benzing, Christian||Krenzien, Felix||Bartels, Michael||Eichfeld, Uwe||Schmelzle, Moritz||Bahra, Marcus||Pascher, Andreas||Wiltberger, Georg","2019-05-16T15:06:14Z","2019-05-16T15:06:14Z","2018","Introduction: M2-polarized tumor-associated macrophages (TAMs) and TIE2- expressing monocytes (TEMs) are associated with angiogenesis and have been identified as a potential prognostic marker in several solid tumors, including hepatobiliary malignancies. However, little is known regarding their influence on tumor progression and patient survival in pancreatic ductal adenocarcinoma (PDAC). Results: Patients with tumors characterized by the presence of CD163+ TAMs or TEMs in TCA or TIF, respectively, showed a significantly decreased 1-, 3- and 5-year overall and recurrence-free survival compared to patients without CD163+ TAMs or TEMs (all ρ < 0.05). Patients with TEMs in TCA showed a higher incidence of tumor recurrence (ρ < 0.05). Furthermore, the presence of CD163+ TAMs was associated with a higher tumor MVD (ρ < 0.05). Conclusions: Presence of M2-polarized TAMs and TEMs is associated with a decreased overall and recurrence-free survival of patients with PDAC. Materials and methods: The localization and density of CD163+ M2-polarized TAMs and TEMs were quantified in the tumor central area (TCA) and tumor-infiltrating front (TIF) in human PDAC tissue (n = 106) and correlated to clinicopathological characteristics, tumor recurrence rates and patient survival. In parallel, tumor microvascular density (MVD) and the density of angiopoietin-positive tumor cells were quantified. Statistical analysis was performed using SPSS software.","https://refubium.fu-berlin.de/handle/fub188/24584||http://dx.doi.org/10.17169/refubium-2347","eng","https://creativecommons.org/licenses/by/3.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","TIE2-expressing monocytes||pancreatic adenocarcinoma||tumor-associated macrophages||M2-macrophages||angiogenesis","TIE2-expressing monocytes and M2-polarized macrophages impact survival and correlate with angiogenesis in adenocarcinoma of the pancreas","Wissenschaftlicher Artikel","open access","10.18632/oncotarget.25690","Oncotarget","51","Impact Journals LLC","29726","29715","30038715","9","1949-2553","Charité - Universitätsmedizin Berlin","no"