id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.issn,refubium.affiliation,refubium.resourceType.isindependentpub "15e2b9a7-954b-4ccc-98dc-180058f87afc","fub188/15","Ritschl, Paul V.||Günther, Julia||Hofhansel, Lena||Kühl, Anja A.||Sattler, Arne||Ernst, Stefanie||Friedersdorff, Frank||Ebner, Susanne||Weiss, Sascha||Bösmüller, Claudia||Weissenbacher, Annemarie||Oberhuber, Rupert||Cardini, Benno||Öllinger, Robert||Schneeberger, Stefan||Biebl, Matthias||Denecke, Christian||Margreiter, Christian||Resch, Thomas||Aigner, Felix||Maglione, Manuel||Pratschke, Johann||Kotsch, Katja","2019-04-10T12:08:41Z","2019-04-10T12:08:41Z","2018","Introduction: Although prone to a higher degree of ischemia reperfusion injury (IRI), the use of extended criteria donor (ECD) organs has become reality in transplantation. We therefore postulated that peri-operative perfusion of renal transplants with anti-human T-lymphocyte globulin (ATLG) ameliorates IRI and results in improved graft function. Methods: We performed a randomized, single-blinded, placebo-controlled trial involving 50 kidneys (KTx). Prior to implantation organs were perfused and incubated with ATLG (AP) (n = 24 kidney). Control organs (CP) were perfused with saline only (n = 26 kidney). Primary endpoint was defined as graft function reflected by serum creatinine at day 7 post transplantation (post-tx). Results: AP-KTx recipients illustrated significantly better graft function at day 7 post-tx as reflected by lower creatinine levels, whereas no treatment effect was observed after 12 months surveillance. During the early hospitalization phase, 16 of the 26 CP-KTx patients required dialysis during the first 7 days post-tx, whereas only 10 of the 24 AP-KTx patients underwent dialysis. No treatment-specific differences were detected for various lymphocytes subsets in the peripheral blood of patients. Additionally, mRNA analysis of 0-h biopsies post incubation with ATLG revealed no changes of intragraft inflammatory expression patterns between AP and CP organs. Conclusion: We here present the first clinical study on peri-operative organ perfusion with ATLG illustrating improved graft function in the early period post kidney transplantation.","https://refubium.fu-berlin.de/handle/fub188/24355||http://dx.doi.org/10.17169/refubium-2127","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","kidney transplantation||organ preservation||ATLG||ischemia reperfusion injury||RCT","Graft pre-conditioning by peri-operative perfusion of kidney allografts with rabbit anti-human T-lymphocyte globulin results in improved kidney graft function in the early post-transplantation period - a prospective, randomized placebo-controlled trial","Wissenschaftlicher Artikel","open access","1911","10.3389/fimmu.2018.01911","Frontiers in Immunology","Frontiers Media S.A.","30197644","9","1664-3224","Charité - Universitätsmedizin Berlin","no"