id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.issn,refubium.affiliation,refubium.resourceType.isindependentpub "c9bd7da2-feac-4c5f-acc1-e1baf9a9d754","fub188/15","Petersen, Ansgar||Princ, Alexander||Korus, Gabriela||Ellinghaus, Agnes||Herrera, Aarón||Klaumünzer, Amelie||Schreivogel, Sophie||Woloszyk, Anna||Schmidt-Bleek, Katharina||Geissler, Sven||Duda, Georg [u.v.m]","2019-04-02T14:36:21Z","2019-04-02T14:36:21Z","2018","Biomaterials developed to treat bone defects have classically focused on bone healing via direct, intramembranous ossification. In contrast, most bones in our body develop from a cartilage template via a second pathway called endochondral ossification. The unsolved clinical challenge to regenerate large bone defects has brought endochondral ossification into discussion as an alternative approach for bone healing. However, a biomaterial strategy for the regeneration of large bone defects via endochondral ossification is missing. Here we report on a biomaterial with a channel-like pore architecture to control cell recruitment and tissue patterning in the early phase of healing. In consequence of extracellular matrix alignment, CD146+ progenitor cell accumulation and restrained vascularization, a highly organized endochondral ossification process is induced in rats. Our findings demonstrate that a pure biomaterial approach has the potential to recapitulate a developmental bone growth process for bone healing. This might motivate future strategies for biomaterial-based tissue regeneration.","https://refubium.fu-berlin.de/handle/fub188/24278||http://dx.doi.org/10.17169/refubium-2050","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","endochondral ossification","A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects","Wissenschaftlicher Artikel","open access","4430","10.1038/s41467-018-06504-7","Nature Communications","Nature Publishing Group","30361486","9","2041-1723","Charité - Universitätsmedizin Berlin","no"