id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject,dc.subject.ddc,dc.title,dc.title.subtitle,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.url,refubium.affiliation[de],refubium.mycore.derivateId,refubium.mycore.fudocsId,refubium.note.author,refubium.resourceType.isindependentpub "4b8c43b6-e401-4130-b4b2-0d632262658a","fub188/15","Lichtenauer, Michael||Wernly, Bernhard||Ohnewein, Bernhard||Franz, Marcus||Kabisch, Bjoern||Muessig, Johanna||Masyuk, Maryna||Lauten, Alexander||Schulze, Paul Christian||Hoppe, Uta C.||Kelm, Malte||Jung, Christian","2018-06-08T10:46:53Z","2017-11-17T12:03:45.330Z","2017","The lactate/albumin ratio has been reported to be associated with mortality in pediatric patients with sepsis. We aimed to evaluate the lactate/albumin ratio for its prognostic relevance in a larger collective of critically ill (adult) patients admitted to an intensive care unit (ICU). A total of 348 medical patients admitted to a German ICU for sepsis between 2004 and 2009 were included. Follow-up of patients was performed retrospectively between May 2013 and November 2013. The association of the lactate/albumin ratio (cut-off 0.15) and both in-hospital and post-discharge mortality was investigated. An optimal cut-off was calculated by means of Youden’s index. The lactate/albumin ratio was elevated in non-survivors (p < 0.001). Patients with an increased lactate/albumin ratio were of similar age, but clinically in a poorer condition and had more pronounced laboratory signs of multi-organ failure. An increased lactate/albumin ratio was associated with adverse in-hospital mortality. An optimal cut-off of 0.15 was calculated and was associated with adverse long-term outcome even after correction for APACHE2 and SAPS2. We matched 99 patients with a lactate/albumin ratio >0.15 to case-controls with a lactate/albumin ratio <0.15 corrected for APACHE2 scores: The group with a lactate/albumin ratio >0.15 evidenced adverse in-hospital outcome in a paired analysis with a difference of 27% (95%CI 10–43%; p < 0.01). Regarding long- term mortality, again, patients in the group with a lactate/albumin ratio >0.15 showed adverse outcomes (p < 0.001). An increased lactate/albumin ratio was significantly associated with an adverse outcome in critically ill patients admitted to an ICU, even after correction for confounders. The lactate/albumin ratio might constitute an independent, readily available, and important parameter for risk stratification in the critically ill. View Full- Text","9 S.","https://refubium.fu-berlin.de/handle/fub188/21076||http://dx.doi.org/10.17169/refubium-24373","eng","http://creativecommons.org/licenses/by/4.0/","critically ill patients||lactate||albumin||lactate/albumin ratio||ICU||risk stratification||risk score","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit","The Lactate/Albumin Ratio","A Valuable Tool for Risk Stratification in Septic Patients Admitted to ICU","Wissenschaftlicher Artikel","open access","Int. J. Mol. Sci. - 18 (2017), 9, Artikel Nr. 1893","10.3390/ijms18091893","http://www.mdpi.com/1422-0067/18/9/1893","Charité - Universitätsmedizin Berlin","FUDOCS_derivate_000000009124","FUDOCS_document_000000028494","Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.","no"