id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject,dc.subject.ddc,dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.url,refubium.affiliation[de],refubium.mycore.derivateId,refubium.mycore.fudocsId,refubium.note.author,refubium.resourceType.isindependentpub "a6aa5b73-5c87-483b-902b-05566adc127f","fub188/16","Meininger, Isabel||Griesbach, Richard A.||Hu, Desheng||Gehring, Torben||Seeholzer, Thomas||Bertossi, Arianna||Kranich, Jan||Oeckinghaus, Andrea||Eitelhuber, Andrea C.||Greczmiel, Ute||Gewies, Andreas||Schmidt-Supprian, Marc||Ruland, Juergen||Brocker, Thomas||Heissmeyer, Vigo||Heyd, Florian||Krappmann, Daniel","2018-06-08T03:58:47Z","2016-05-12T10:34:57.418Z","2016","MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we demonstrate here that MALT1 alternative splicing supports optimal T-cell activation. Inclusion of exon7 in MALT1A facilitates the recruitment of TRAF6, which augments MALT1 scaffolding function, but not protease activity. Naive CD4+ T cells express almost exclusively MALT1B and MALT1A expression is induced by TCR stimulation. We identify hnRNP U as a suppressor of exon7 inclusion. Whereas selective depletion of MALT1A impairs T-cell signalling and activation, downregulation of hnRNP U enhances MALT1A expression and T-cell activation. Thus, TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.","15 S.","https://refubium.fu-berlin.de/handle/fub188/16334||http://dx.doi.org/10.17169/refubium-20517","eng","http://creativecommons.org/licenses/by/4.0/","Biological sciences||Immunology||Molecular biology","500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie","Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells","Wissenschaftlicher Artikel","open access","Nature Communications. - 7 (2016), Artikel Nr. 11292","10.1038/ncomms11292","http://www.nature.com/ncomms/2016/160412/ncomms11292/full/ncomms11292.html","Biologie, Chemie, Pharmazie","FUDOCS_derivate_000000006389","FUDOCS_document_000000024508","Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.","no"