C.4 simulation data of miRNA Inhibitor let_7b_drug0 let_7c_drug1 let_7e_drug2 let_7i_drug3 mir_100_drug29 mir_106a_drug30 mir_107_drug31 mir_10a_drug5 mir_10b_drug6 mir_126_drug32 mir_130a_drug33 mir_132_drug34 mir_134_drug35 mir_141_drug36 mir_143_drug37 mir_144_drug38 mir_145_drug39 mir_146a_drug40 mir_149_drug41 mir_150_drug42 mir_155_drug43 mir_15a_drug7 mir_15b_drug8 mir_17_drug9 mir_181c_drug44 mir_182_drug45 mir_183_drug46 mir_184_drug47 mir_186_152_drug99 mir_188_drug48 mir_18a_drug10 mir_18b_drug11 mir_191_drug49 mir_192_drug50 mir_195_drug51 mir_198_drug52 mir_19a_drug12 mir_200a_drug53 mir_200b_drug54 mir_200c_1305_drug95 mir_202_drug55 mir_203_drug56 mir_205_drug57 mir_206_drug58 mir_20a_drug13 mir_20b_drug14 mir_210_drug59 mir_212_drug60 mir_214_drug61 mir_215_drug62 mir_217_drug63 mir_21_drug15 mir_221_drug64 mir_222_drug65 mir_223_drug66 mir_22_drug16 mir_23a_drug17 mir_23b_drug18 mir_25_drug19 mir_26b_drug20 mir_27a_drug21 mir_29c_drug22 mir_30b_drug23 mir_31_98_133b_drug97 mir_3200_drug94 mir_335_drug67 mir_34a_drug24 mir_34b_drug25 mir_363_drug68 mir_370_drug69 mir_372_drug70 mir_373_drug71 mir_375_drug72 mir_378_drug73 mir_421_drug74 mir_424_drug75 mir_433_drug76 mir_449a_drug77 mir_449b_drug78 mir_452_drug79 mir_489_drug80 mir_497_drug81 mir_498_drug82 mir_518b_drug83 mir_564_drug84 mir_575_drug85 mir_630_drug86 mir_638_drug87 mir_654_drug88 mir_658_drug89 mir_663_drug90 mir_671_drug91 mir_765_drug92 mir_7_1_drug4 mir_802_drug93 mir_93_drug26 mir_96_drug27 mir_99a_drug28 mir_DICER_drug98 mir_TRDD_drug96 AP-1 9.43639 1 1 1 1 1 1 1.00388 1.00388 1 1 1 3.58754 1 1 1 1 1 9.38362 1 27.1026 9.44773 1 1.00392 1 1 1.00011 1 1 1 9.44746 1.00392 1 1 1 1 1 1 1 1 1 1 1 27.0345 1.00392 1.00392 1 1 1 1 1 27.0345 1.0039 1.0039 1 1 1 1 1 1 1 1 1 1 1 1 1.0039 1 1.0039 3.58754 1 1 1 9.38362 1 1 0.999963 1 9.38362 1 1 1 1 9.38362 1 1 1 1 1 1 1 1 9.43639 1 1 1 1 1 1 1 Active-NF-KB 1.00642 70.7461 9.20909 1.11052 65.3018 7.78651 1 10.4894 1.00728 148.877 1.10957 1.11052 1 0.999153 0.999153 10.4779 7.78651 1.00728 1 11.0747 126.785 1 1 5.69569 9.20909 9.62064 2.51674 1 1 1 1.10957 1.10957 1 7.78651 0.999153 1.00728 0.999153 9.57598 1.00642 1.00728 1 7.78651 1.00328 1.00728 8.68518 1.10957 1.00728 1 9.19886 1 0.999153 1156.52 151.921 57.96 1 9.23187 0.999153 1.11052 1 7.38011 0.999153 1 1.11052 0.999153 1 57.96 190.25 1 1 10.4894 1 1.11052 7.67077 0.999153 0.999153 1.00728 0.494647 1 1.00778 1 57.96 0.583435 1 1.00778 1 1 1 1 1 0.999153 1 1 1 1.00728 1 1 9.24073 1 1 1 P-TP53-1 5.62234 1 5.62234 1 1 13.1046 1 1 1 13.1046 1 1 2.44579 5.62234 13.1045 1 66.7967 1 13.1046 1 13.1046 66.7965 1 66.7967 1 1 13.1046 1 1 1 1 1 1 13.1046 13.1045 13.1046 1 1 1 1 1 13.1046 1 13.1046 66.7967 1 1 1 1 13.1046 1 13.1046 13.1046 13.1046 1 1 5.62234 1 1 13.1046 13.1045 13.1046 1 1 1 13.1046 13.099 13.1046 1 2.44579 1 5.62234 5.62234 1 1 1 0.99966 1 13.1046 1 13.1046 13.1046 1 13.1046 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-FOXO 1.00284 10.0832 10.5445 1 112.071 5.37061 1 1 1.00284 211.239 0.999998 1 1 0.999998 0.999998 0.999998 5.37061 1.00284 1 1 10.578 1 1 4.44156 10.5445 132.266 37.1206 1 13.1335 1 0.999998 0.999998 1 5.37061 0.999998 1.00284 0.999998 10.578 1.00284 1.00284 1 5.37061 0.999998 1.00284 5.37061 0.999998 1.00284 1 10.5425 1 13.1328 739.262 724.625 61.3703 1 10.0832 0.999998 1 1 5.30086 13.1328 1 1 0.999998 1 61.3703 169.543 1 1 1 1 1 8.21164 0.999998 0.999998 1.00284 0.646537 1 1.00284 1 61.3703 0.516784 1 1.00284 1 1 1 1 1 0.999998 1 1 1 1.00284 1 1 131.776 1 1 1 P-NR4A1-2 1.00284 10.0832 10.5446 1 112.072 5.37056 1 1.00008 1.00292 211.232 0.999998 1 1 0.999998 0.999998 0.999998 5.37056 1.00284 1 1 10.5789 1.00008 1 4.44193 10.5446 10.1192 2.85395 1 1 13.1316 1.00008 1.00008 1 5.37056 0.999998 1.00284 0.999998 10.5781 1.00284 1.00284 1 5.37056 0.999998 1.00284 5.37106 1.00008 1.00284 13.1316 10.5426 1 0.999998 739.256 724.685 61.3754 1 10.0832 0.999998 1 1 5.30078 0.999998 1 1 0.999998 1 61.3698 169.558 1 1.00008 13.1316 1 1 8.21167 0.999998 0.999998 1.00284 0.646545 1 1.00284 1 61.3698 0.516778 1 1.00284 1 1 1 13.1316 1 0.999998 1 1 13.1316 1.00284 1 1 10.084 1 1 1 P-BAD-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 13.2528 13.2528 3.5961 11.3388 10.0553 2.78455 13.2528 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 13.2409 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-MDM2-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 13.2528 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 50.5363 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 13.2528 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 1862.54 13.2528 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-CREB1-3 1.00277 106.542 8.3969 1 28.1868 4.80551 1 1.02356 1.02647 31.8385 0.999998 1 1 0.999998 0.999998 0.999998 4.80551 1.00277 1 1 140.651 1.02368 1 59.9022 8.3969 8.13173 2.72421 1 1 1 1.0238 1.0238 1 4.80551 0.999998 1.00277 0.999998 8.41777 1.00277 1.00277 1 4.80551 0.999998 1.00277 5.49388 1.0238 1.00277 1 8.39566 1 0.999998 475.671 602.637 61.6384 1 8.10889 0.999998 1 1 4.751 0.999998 1 1 0.999998 1 23.4415 172.931 13.143 1.02368 1 1 1 6.88131 0.999998 0.999998 13.1804 0.653015 1 1.00277 1 23.4415 0.523564 1 1.00277 1 1 1 1 1 0.999998 1 1 1 1.00277 13.143 1 8.10935 13.143 1 1 P-MYC-2 5.57619 5.57052 1 1 5.57052 5.57159 5.57052 60.2528 60.2638 0.999944 1 5.57052 5.57052 5.57052 5.57052 1 5.57159 5.57159 5.57052 5.57052 484.728 484.638 1 690.495 5.57052 1.0002 1.02623 5.57052 1 1 690.54 690.54 1 1.0002 5.57052 5.57159 5.57052 1.0002 1.0002 1.0002 1 1.0002 1 1.0002 690.688 690.54 5.57159 1 5.57052 1 1 5.57159 484.638 484.638 1 5.57052 5.57052 5.57052 1 5.57052 1 1 1 5.35641 1 1 483.101 5.57052 87.3464 1 5.57052 1 1 1 5.57052 1.0002 0.985881 1 5.57159 1 1 0.999944 1 5.57159 1 1 1 1 1 1 1 1 1 1.0002 1 1 1 5.57052 1 1 P-ELK1-1 1.00107 1 1 1 1 1.0002 1 60.2532 60.2641 0.999942 1 1 1 1 13.225 1 13.2276 13.2276 1 1 1151.3 87.2339 1 1616.96 1 1.0002 1.02623 1 1 1 122.384 122.384 1 1.0002 1 1.0002 1 1.0002 1.0002 1.0002 1 1.0002 1 1.0002 122.41 122.384 1.0002 1 1 1 1 13.2276 87.2339 87.2339 1 1 1 1 1 1 1 1 1 1 1 1 1147.4 1 87.2339 1 1 1 1 1 1 13.2276 0.985871 1 1.0002 1 1 0.999942 1 1.0002 1 1 1 1 1 1 1 1 1 1.0002 1 1 1 1 1 1 P-ATF1-1 1.0002 1 1 1 1 1.00012 1 60.7109 60.7177 0.99998 1 1 1 1 1 1 1.00012 1.00012 13.3745 1 85.9779 85.9683 1 144.674 1 1.00012 1.02811 1 1 1 144.678 144.678 1 1.00012 1 1.00012 1 1.00012 1.00012 1.00012 1 1.00012 1 1.00012 144.699 144.678 1.00012 1 1 1 1 1.00012 85.9683 85.9683 1 1 1 1 1 1 13.3745 1 1 1 1 1 1161.51 1 85.9683 1 1 1 1 1 1 1.00012 0.994509 1 1.00012 1 1 0.99998 1 1.00012 1 1 1 1 1 1 1 1 1 1.00012 1 1 1 1 1 1 P-RPS6KB2-1 1.00284 10.0832 10.5445 1 112.071 5.37061 1 1 1.00284 211.239 0.999998 1 1 0.999998 0.999998 0.999998 5.37061 1.00284 1 1 10.578 1 1 4.44156 10.5445 10.1192 2.85394 1 1 1 0.999998 0.999998 1 5.37061 0.999998 1.00284 0.999998 10.578 1.00284 1.00284 1 5.37061 0.999998 1.00284 5.37061 0.999998 1.00284 1 10.5425 1 0.999998 739.262 724.625 61.3703 1 10.0832 0.999998 1 1 5.30086 0.999998 1 1 0.999998 1 61.3703 169.543 1 1 1 1 1 8.21164 0.999998 0.999998 1.00284 0.646537 1 1.00284 1 61.3703 0.516784 1 1.00284 1 1 1 1 1 0.999998 1 1 1 1.00284 1 1 10.0839 1 1 1 P-TSC2-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-CHUK-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-MAP3K8-1 1.00181 132.482 11.3388 1 119.065 3.76667 1 13.2528 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 13.2409 3.76667 1.00268 1 13.2528 149.456 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 13.2528 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-GSK3 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-CASP9-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 13.2409 0.999123 3.76667 1.00268 1 1 11.3607 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 7588.36 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 13.2528 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-AKT1S1-1 1.00181 10.0123 11.3388 1 119.065 3.76667 1 1 1.00268 53.0574 0.999123 1 1 0.999123 0.999123 0.999123 3.76667 1.00268 1 1 11.3607 1 1 3.5961 11.3388 10.0553 2.78455 1 1 1 0.999123 0.999123 1 3.76667 0.999123 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 1.00268 3.76667 0.999123 1.00268 1 11.3287 1 0.999123 566.115 561.193 44.9473 1 10.0123 0.999123 1 1 3.74593 0.999123 1 1 0.999123 1 45.0358 140.795 1 1 1 1 1 7.99914 0.999123 0.999123 1.00268 0.940427 1 1.00181 1 45.0358 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 1 10.021 1 1 1 P-CDKN1 1.00181 10.0123 11.3388 1 119.065 50.5363 1 1 1.00268 53.0574 0.999123 1 1 0.999123 13.2409 0.999123 50.5363 1.00268 13.2528 13.2528 11.3607 1 1 3.5961 11.3388 133.065 36.7031 1 1 1 0.999123 0.999123 1 50.5363 13.2409 1.00268 0.999123 11.3607 1.00181 1.00268 1 3.77416 0.999123 13.2887 50.5363 13.2409 1.00268 1 11.3287 13.2528 0.999123 7588.36 7535.13 601.677 1 10.0123 0.999123 1 13.2528 3.74593 13.2409 1 1 0.999123 1 45.0358 1862.54 1 1 1 13.2528 1 7.99914 0.999123 0.999123 1.00268 0.940427 13.2528 1.00181 1 602.853 0.51352 1 1.00181 1 1 1 1 1 0.999123 1 1 1 1.00268 1 13.2528 10.021 1 1 1 C.6 Validation of ligand activations VIL2 MSTN ARTN IL9 NDP ANGPT1 ANGPT2 ANGPTL1 AREG TGFA IL7 BDNF ADIPOQ BTC GDNF lipopolysaccharide PDGFC Testosterone BMP NRTN GDF11 Estradiol_C00951_ ANGPT4 SFRP WNT WNT_CA FGF HH IFNA DLL JAG NRG1_2 NRG3_4 PSPN NTF4 CNTF CNTN1 EFNA EFNB ACTIVIN CSF2 CSF3 EGF EPO EREG FASLG FIGF GCG GH1 GH2 HBEGF HGF IFNB1 IFNG IGF1 IGF2 IL10 IL12A IL12B IL13 IL15 IL2 IL3 IL4 IL5 IL6 IL8 INS KITLG LEP LIF LY96 TNF NGF NTF3 OSM PDGFA PDGFB PDGFD PGF PRL TGFB1 TGFB2 TGFB3 THBS1 TNFSF10 VEGFA VEGFB VEGFC WIF1 TSLP IL11 CTF1 P-MCF2-2 1.97713e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.03241e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-SMAD2_3 6.37774e+09 4.93998e+10 2.77132e+09 5.20988e+09 1 2.66801e+09 1 2.66801e+09 2.76979e+09 2.66022e+09 8.9747e+09 2.73257e+09 1 2.76929e+09 2.77172e+09 1 3.75514e+09 1 1 2.77137e+09 2.81191e+09 9.68362e+09 1 1 1 2.85109e+09 2.84429e+09 1 4.77127e+09 1 1 5.80492e+09 1.00183e+10 2.77137e+09 1 5.62789e+09 1 2.10439e+09 2.78131e+09 7.79472e+09 5.08423e+09 7.50071e+09 2.66982e+09 7.05509e+09 2.77058e+09 1 3.31278e+09 8.02749e+09 2.66148e+09 8.90931e+09 2.77021e+09 3.82342e+09 4.71053e+09 1.58073e+09 1.69518e+07 1.34863e+07 7.61538e+09 225.856 225.856 1.02821e+10 7.40641e+09 7.37586e+09 8.11128e+09 9.96938e+09 8.07029e+09 7.83824e+09 2.76747e+09 1.03745e+10 2.65761e+09 1.53787e+09 7.80173e+09 1 1 3.75565e+09 3.40555e+09 7.48271e+09 3.98912e+09 2.77517e+09 2.76736e+09 3.03454e+09 2.77078e+09 8.30543e+09 9.55003e+09 9.55004e+09 1 1 2.85564e+09 3.02793e+09 3.31394e+09 1 7.70991e+09 7.8826e+09 8.3614e+09 P-CRK-1 1 1 4.50937e+10 1 1 9.80034e+08 1 9.80034e+08 1 1 1 1 1 1 4.75064e+10 1 1 1 1 4.75064e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 4.75064e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-STAT1-2 1 1 1 3.76617e+09 1 1 1 1 4.88099e+11 4.99748e+11 1.72261e+10 1 1 2.52307e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.37751e+10 1 1 1.16112e+11 1 1 1 1.31937e+10 1 2.79467e+10 1 1 1 2.95905e+10 2.16995e+11 1 2.52086e+11 1 1 1 8.96336e+09 3.71756e+09 2.5143e+11 1 2.5372e+10 7.50786e+09 1 1 2.1265e+10 1 1 1 3.0286e+10 3.22728e+10 1 1 1 8.70245e+09 1 1 1 1 2.24278e+10 1 1 1 1 3.00711e+10 1 1 1 1 5.36678e+09 1 1 1 1 1 1 1 1 1 2.47462e+10 2.32699e+10 6.06583e+10 CTNNB1-1 2.54838e+09 1 3.71925e+09 1.57238e+09 9.84487e+08 3.37502e+09 1 3.37502e+09 6.12683e+07 6.37017e+07 8.00875e+08 2.86467e+09 1 1.15019e+08 4.15036e+09 1 2.54932e+09 1 1 4.15929e+09 1.45375e+09 1.71505e+09 1 9.85928e+08 9.84445e+08 1.74013e+09 2.75376e+09 9.97512e+08 5.0684e+08 1 1 1.56971e+08 1.93038e+09 4.15929e+09 1 1.25641e+09 1 1.32408e+09 5.26899e+09 1.45499e+09 1.59569e+09 6.05068e+08 2.02623e+08 2.07361e+09 1.15509e+08 1 2.54851e+09 2.30245e+09 3.11302e+09 1.91342e+09 1.15815e+08 2.37876e+09 4.97552e+08 1.14087e+09 1.40174e+07 9.66854e+06 6.32013e+08 271.538 271.538 1.99931e+09 4.783e+08 4.36966e+08 1.63865e+09 1.63802e+09 1.62518e+09 1.35997e+09 3.23374e+09 1.97524e+09 3.64483e+09 1.08191e+09 6.58192e+08 1 1 1.94614e+09 2.52095e+09 6.03052e+08 2.54287e+09 3.38996e+09 3.37706e+09 2.9102e+09 3.28255e+09 3.1057e+09 1.49298e+09 1.91543e+09 1 1 3.01068e+09 2.91727e+09 2.33023e+09 9.86394e+08 5.67217e+08 6.39279e+08 3.37086e+08 P-DOK2-1 1 1 1 1 1 2.73298e+09 1 2.73298e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ANGPT2-1:TEK-2 1 1 1 1 1 1 4.53383e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-PTK2-1 1 1 1 1 1 1.33339e+12 1 1.33339e+12 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 9.7041e+12 1.88085e+13 1 1 1 1 1 1 1 1 1 1.15708e+12 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.91522e+13 1 4.19099e+13 1 1 1 1 1 1 1 1 2.084e+12 2.57722e+12 1 1.14173e+12 2.06165e+13 1 1 1 1 1 1 1 1 1 1 1 P-PTPN11-3 1 1 1 7.89365e+06 1 1 1 1 3.7318e+10 4.11539e+10 1 1 1 3.4541e+10 1 1 1.67981e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.36054e+10 1 3.44638e+10 1 1 1 1 1 3.45377e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.48203e+08 6.25105e+07 3.39179e+07 4.2596e+09 1 1 1 1 1 1 4.17444e+09 4.27658e+09 1 1 1 1 1 HRAS-2:GTP 3.59747e+08 1 1.51092e+09 69385.8 1 1 1 1 1 2.83463e+08 623036 1 1 9.83018e+06 1.52689e+09 1 1 1 1 1.52599e+09 1 2.27223e+06 1 1 1 1 9.86247e+07 1 1 1 1 1.77912e+07 8.03501e+06 1.52599e+09 1 1 1 1.45514e+09 1.14586e+09 1 1 1 1.35861e+08 3.00534e+06 1.29694e+08 1 1 1.29715e+08 288367 1 9.67274e+06 6.48788e+07 1 1 1 1 1 1 1 1 986901 1.02422e+06 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 309167 1 1 1 1 1 1 1 1 1 1.05048e+06 1 1 P-STAT3-1 1.34405e+10 1 1.35694e+10 6.57822e+09 1 1.35163e+10 1 1.35163e+10 1.55279e+10 1.55742e+10 1.0658e+10 1.35227e+10 1 1.50554e+10 1.35714e+10 1 1.34787e+10 1 1 1.35697e+10 1 1.12825e+10 1 1 1 1.35665e+10 1.35561e+10 1 6.29425e+09 1 1 1.3562e+10 1.19958e+10 1.35697e+10 1 7.06837e+09 1 1.35792e+10 1.39313e+10 1 6.48496e+09 9.12234e+09 1.49825e+10 1.33677e+10 1.50532e+10 1 1.35531e+10 1.324e+10 1.35178e+10 1.10735e+10 1.50648e+10 1.35151e+10 6.2568e+09 2.55871e+09 1.4858e+08 1.32014e+08 9.23229e+09 430639 430639 1.25414e+10 9.09078e+09 9.07918e+09 9.75176e+09 1.19077e+10 9.70875e+09 9.43433e+09 1.35489e+10 1.25731e+10 1.35152e+10 2.55327e+09 9.40863e+09 1 1 1.34843e+10 1.35191e+10 9.10517e+09 1.37415e+10 1.35812e+10 1.35486e+10 1.35465e+10 1.35491e+10 1.35178e+10 1 1 1 1 1.35125e+10 1.35326e+10 1.35413e+10 1 9.34182e+09 9.49199e+09 1.01009e+10 Active-CASP2-1 1 1 1 1 1 1 1 1 1 1 1 2.63278e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.62674e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.24232e+10 2.62853e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-ELAVL1-1 0.999986 1 1 1 1 1 1 1 1 1 1 1 0.825325 1 1 1 1 1 1 1 1 0.986449 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0.907328 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 NRAS-1:GTP 7.84036e+08 1 1.17826e+09 59015 1 1.15077e+09 1 1.15077e+09 1.13651e+09 1.1501e+09 592823 1.10113e+09 1 1.14331e+09 1.22562e+09 1 1.04289e+09 1 1 1.1788e+09 1 1.12371e+06 1 1 1 9.95679e+08 1.09362e+09 1 7158.3 1 1 9.56681e+08 2.45315e+06 1.1788e+09 1 9015.15 1 1.19359e+09 1.23598e+09 1 7452.61 17618.3 1.16211e+09 6.21863e+08 1.14763e+09 1 1.05896e+09 3.64284e+08 1.15161e+09 8.15008e+06 1.14343e+09 1.03105e+09 7029.56 1691.2 1 1 17865 1 1 129767 980992 1.04615e+06 22174.6 61922.7 21803.8 19918.6 1.15274e+09 244592 1.17502e+09 1764.62 19639.1 1 1 1.04333e+09 1.04969e+09 17505.3 1.05699e+09 1.16088e+09 1.15552e+09 1.12189e+09 1.15202e+09 1.15165e+09 1 1 1 1 1.12016e+09 1.12231e+09 1.06758e+09 1 18549.2 20268.3 25608.7 P-NCK1-1 1 1 5.15093e+10 1 1 2.53237e+09 1 2.53237e+09 1 1 1 1 1 1 5.15093e+10 1 2.2034e+08 1 1 5.15093e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 5.15093e+10 1 1 1 3.14126e+10 7.17296e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.95095e+08 9.20876e+07 4.86941e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-TRAF6-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.09107e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.04834e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 KRAS-2:GTP 7.91565e+08 1 1.1289e+09 207378 1 1.08044e+09 1 1.08044e+09 1.13352e+09 1.13561e+09 429440 1.03349e+09 1 1.1317e+09 1.13015e+09 1 9.74531e+08 1 1 1.13003e+09 1 516407 1 1 1 9.5602e+08 1.02696e+09 1 898034 1 1 1.03197e+09 2.65114e+06 1.13003e+09 1 256291 1 1.17623e+09 1.13592e+09 1 190829 887278 1.142e+09 6.94649e+08 1.13146e+09 1 9.93081e+08 4.65613e+08 1.06844e+09 2.36021e+07 1.1318e+09 9.65108e+08 911102 1617.3 6.82004e+07 6.13109e+07 786978 149755 149755 815402 523891 562589 1.17157e+06 612497 1.11933e+06 796501 1.06897e+09 8.6934e+07 1.09662e+09 64205.6 804910 1 1 9.74284e+08 9.84238e+08 889368 9.8252e+08 1.07661e+09 1.07364e+09 1.05748e+09 1.06869e+09 1.06829e+09 1 1 1 1 1.05959e+09 1.05787e+09 9.9902e+08 1 468360 839450 1.81323e+06 AR-1:Dihydrotestosterone(C03917) 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.89344e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-SMAD1_5_8:SMAD4-1 1.06704e+07 1 5.86046e+06 8.08692e+06 1 6.08139e+06 1 6.08139e+06 4.08686e+06 4.24267e+06 1.18098e+07 6.09553e+06 1 4.57315e+06 5.86085e+06 1 8.02235e+06 1 1.37095e+07 5.86007e+06 1.06194e+07 1.30079e+07 1 1 1 5.58474e+06 6.1683e+06 1 6.34026e+06 1 1 1.14643e+07 1.39762e+07 5.86007e+06 1 8.37198e+06 1 3.44393e+06 6.07007e+06 1.06059e+07 7.64699e+06 9.96371e+06 855659 1.19486e+07 4.57701e+06 1 7.12246e+06 1.22044e+07 5.85236e+06 1.15011e+07 4.57843e+06 8.12954e+06 5.7957e+06 2.627e+06 22571.8 17223.5 9.64904e+06 1 1 1.487e+07 8.45173e+06 8.15694e+06 1.07414e+07 1.35417e+07 1.06843e+07 1.05945e+07 5.8863e+06 1.52226e+07 5.88412e+06 2.2299e+06 1.04191e+07 1 1 8.02177e+06 7.3747e+06 9.94319e+06 8.38749e+06 6.03263e+06 5.95679e+06 7.09272e+06 5.85531e+06 6.09004e+06 6.12152e+06 6.10135e+06 1 1 6.54395e+06 7.08733e+06 7.22755e+06 1 9.72971e+06 1.05206e+07 1.10216e+07 Active-PI3K:NRTN-1:RET-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.21808e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-MAPK14-2 2.2376e+10 1.29009e+10 2.50274e+10 1.89916e+09 1 2.42241e+10 1 2.42241e+10 2.4411e+10 2.45812e+10 6.02368e+09 2.41377e+10 1 2.44041e+10 2.50425e+10 1 2.38718e+10 1 1 2.50426e+10 1.31469e+09 8.19741e+09 1 1 1 2.39454e+10 2.41261e+10 1 1.73179e+09 1 1 2.18495e+10 1.03322e+10 2.50426e+10 1 2.16431e+09 1 2.41899e+10 2.41259e+10 1.31473e+09 2.02701e+09 3.9537e+09 2.4392e+10 2.24704e+10 2.4398e+10 1 2.39846e+10 2.00297e+10 2.4283e+10 9.71549e+09 2.43982e+10 2.38605e+10 1.73494e+09 4.67858e+08 1 1 3.83802e+09 1 1 1.3185e+10 3.59812e+09 3.568e+09 5.09871e+09 9.24378e+09 4.6132e+09 4.16336e+09 2.4196e+10 1.50853e+10 2.43809e+10 4.82419e+08 4.11104e+09 1 1 2.19586e+10 2.39398e+10 3.74571e+09 2.38325e+10 2.42316e+10 2.41662e+10 2.40867e+10 2.42676e+10 2.45147e+10 1 1.48736e+10 1 1 2.41066e+10 2.40874e+10 2.4056e+10 1 3.95095e+09 4.21429e+09 4.97813e+09 Active-PRKACA-1 4.56707e+06 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.81116e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 318703 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ANGPT4-1:TEK-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.53383e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WNT:SFRP 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.64903e+13 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CTNNB1-1:TCF 2.36323e+09 1 3.66122e+09 1.83478e+09 1.54688e+09 3.22432e+09 1 3.22432e+09 2.8824e+08 2.41602e+08 1.03856e+09 2.87034e+09 1 3.58572e+08 3.69105e+09 1 2.43261e+09 1 1 3.69021e+09 2.22139e+09 2.39549e+09 1 1.5509e+09 1.54875e+09 1.94571e+09 2.81582e+09 1.57113e+09 7.41803e+08 1 1 4.72622e+08 2.26136e+09 3.69021e+09 1 1.60508e+09 1 1.95264e+09 5.17744e+09 2.22728e+09 1.86959e+09 9.18868e+08 6.44035e+08 2.34436e+09 3.59058e+08 1 2.50046e+09 2.19303e+09 3.10908e+09 2.20259e+09 3.59324e+08 2.47169e+09 4.67144e+08 8.12304e+08 8.71068e+06 5.93002e+06 8.28808e+08 164.842 164.842 2.03573e+09 5.20929e+08 4.52849e+08 1.91121e+09 1.77273e+09 1.89572e+09 1.67542e+09 3.31174e+09 2.81063e+09 3.60573e+09 8.53613e+08 9.27847e+08 1 1 2.42655e+09 2.52129e+09 9.20958e+08 2.40835e+09 3.31042e+09 3.35152e+09 2.76591e+09 3.18169e+09 3.35396e+09 2.2827e+09 2.31926e+09 1 1 2.8591e+09 2.79294e+09 2.55899e+09 1.54886e+09 7.77836e+08 9.06787e+08 6.75093e+08 P-PLCB 1.40843e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.24473e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7.38175e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-FRS:P-FGFR:FGF 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.10573e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-GLI 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.72135e+12 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-EIF2AK2-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.33194e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.28458e+09 1.12761e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-NOTCH 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.59744e+10 3.48725e+10 1 1 1 1 1 3.62951e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 RBPJ-6:Active-NOTCH 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.09812e+10 2.05411e+10 1 1 1 1 1 1.93676e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ERBB2-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.61945e+10 1 1 1 1 1 1 1 1 1 1 1 1 1.4131e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 PIP3 1 1 4.17607e+09 3.11334e+06 1 3.85792e+09 1 3.85792e+09 3.87819e+09 3.89255e+09 3.5857e+07 8.932e+08 1 3.63075e+09 4.17607e+09 1 1.40535e+08 1 1 4.17607e+09 1 1.49548e+07 1 1 1 1 7.62073e+08 1 1.20724e+07 1 1 1.77259e+08 9.51543e+07 4.17607e+09 1 7.4388e+06 1 3.90652e+09 3.86418e+09 1 5.31077e+06 2.88424e+07 1.84436e+09 5.58813e+07 3.62541e+09 1 2.42008e+08 1 3.8529e+09 800008 3.63803e+09 1.4765e+08 1.49457e+07 2.01241e+06 1 1 2.38271e+07 1 1 5.67234e+07 4.00122e+07 4.47821e+07 3.81255e+07 8.7399e+07 3.74135e+07 2.2443e+07 3.85287e+09 9.15157e+07 3.96735e+09 2.22134e+06 2.22394e+07 1 1 1.41218e+08 2.01558e+08 2.93867e+07 1.24953e+08 3.85445e+09 3.85368e+09 5.41852e+08 3.85287e+09 3.85287e+09 1 1 1 1 6.34118e+08 5.44916e+08 2.41884e+08 1 2.91344e+07 2.34106e+07 7.12043e+07 PSPN-1:RET-1:GRB2-1:SOS1-1:SHC1-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.06451e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-CASP3-1 1 1 1 1 1 1 1 1 1 1 1 1.80787e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.00958e+09 1 1 1 1 1 1 1 1 1 1 1.76197e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.75234e+09 1.66511e+09 1.80911e+09 1 1 1 1 1 1 1 1 1 1 1.77917e+09 1 1 1 1 1 1 1 P-STAT5 1 1 1 7.32629e+07 1 1 1 1 3.32243e+10 3.21796e+10 1.8038e+08 1 1 3.0373e+10 1 1 9.16702e+08 1 1 1 1 1 1 1 1 1 1 1 4.64817e+08 1 1 5.04261e+08 5.68623e+08 1 1 1.2545e+08 1 1 1 1 9.51454e+07 3.87891e+08 3.01834e+10 1.12791e+09 3.03602e+10 1 1 1 1.00287e+08 5.57965e+07 3.04477e+10 1 6.00272e+08 1.16633e+08 1 1 1 1 1 1 5.89602e+08 6.71002e+08 4.6207e+08 1 4.44241e+08 1.25217e+08 1 1 1 1 2.71855e+08 1 1 1 1 3.95569e+08 8.18218e+08 3.76224e+08 2.03633e+08 1.15121e+10 1.28316e+07 1 1 1 1 1 1.14159e+10 1.1549e+10 1 1 3.76734e+08 1.33707e+08 1.07006e+08 SPEN-1:Active-NOTCH 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.09812e+10 2.05411e+10 1 1 1 1 1 1.93676e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-FYN-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.14126e+10 7.17296e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.92079e+10 1 1 1 1 1 1 1 1 1.54194e+09 1.87171e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-RGS3-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.09451e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-SMAD2_3 6.37774e+09 4.93998e+10 2.77132e+09 5.20988e+09 1 2.66801e+09 1 2.66801e+09 2.76979e+09 2.66022e+09 8.9747e+09 2.73257e+09 1 2.76929e+09 2.77172e+09 1 3.75514e+09 1 1 2.77137e+09 2.81191e+09 9.68362e+09 1 1 1 2.85109e+09 2.84429e+09 1 4.77127e+09 1 1 5.80492e+09 1.00183e+10 2.77137e+09 1 5.62789e+09 1 2.10439e+09 2.78131e+09 7.79472e+09 5.08423e+09 7.50071e+09 2.66982e+09 7.05509e+09 2.77058e+09 1 3.31278e+09 8.02749e+09 2.66148e+09 8.90931e+09 2.77021e+09 3.82342e+09 4.71053e+09 1.58073e+09 1.69518e+07 1.34863e+07 7.61538e+09 225.856 225.856 1.02821e+10 7.40641e+09 7.37586e+09 8.11128e+09 9.96938e+09 8.07029e+09 7.83824e+09 2.76747e+09 1.03745e+10 2.65761e+09 1.53787e+09 7.80173e+09 1 1 3.75565e+09 3.40555e+09 7.48271e+09 3.98912e+09 2.77517e+09 2.76736e+09 3.03454e+09 2.77078e+09 8.30543e+09 9.55003e+09 9.55004e+09 1 1 2.85564e+09 3.02793e+09 3.31394e+09 1 7.70991e+09 7.8826e+09 8.3614e+09 P-MAP3K1-1 1.40302e+08 1 2.17898e+09 1.36336e+08 1 1.79167e+09 1 1.79167e+09 3.63612e+09 3.63751e+09 4.75636e+08 1.48105e+09 1 3.55383e+09 2.18577e+09 1 1.21955e+09 1 1 2.18578e+09 1 7.14207e+08 1 1 1 1 1.43539e+09 1 1.17731e+08 1 1 8.3152e+08 8.004e+08 2.18578e+09 1 1.49366e+08 1 1.8553e+09 1.83566e+09 1 4.27529e+08 6.07116e+08 3.50174e+09 4.90575e+08 3.55266e+09 1 1.08516e+09 7.34062e+07 3.13928e+09 6.07247e+07 3.55326e+09 6.31812e+08 1.17883e+08 3.10252e+07 1 1 2.70296e+08 1 1 1.03605e+09 2.52437e+08 2.50078e+08 1.42272e+09 7.06006e+08 6.10065e+08 3.00475e+08 1.78576e+09 1.43951e+09 3.6113e+09 3.25254e+07 2.89623e+08 1 1 9.09235e+08 9.81857e+08 2.63913e+08 1.31879e+09 2.16303e+09 2.00879e+09 1.49014e+09 3.1356e+09 1.76682e+09 1 1 1 1 1.55141e+09 1.49237e+09 1.15848e+09 1 2.78194e+08 2.96837e+08 3.50099e+08 Active-PI3K:P-JAK1-1:P-JAK2-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6.84145e+07 1 1 1 1 1 6.26737e+07 1 1 1 1 1 1 1 1 1 1 1 7.05432e+07 1 1 1 1 1 1 1 1 1 1 1 5.42446e+07 1 1 1 1 5.50205e+07 1 1 1 1 8.78728e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7.36078e+07 1.79162e+08 P-MYC-2 2.38649e+12 1 1.56106e+12 2.6995e+12 1 1.75136e+12 1 1.75136e+12 2.39732e+12 3.33714e+12 3.34043e+12 1.6074e+12 1 2.17752e+12 1.56602e+12 1 1.61267e+12 1 1 1.56575e+12 4.43212e+11 1.99489e+12 1 1 1 1.65369e+12 1.59884e+12 1 2.89582e+12 1 1 2.14935e+12 1.82921e+12 1.56575e+12 1 2.59347e+12 1 1.45273e+12 1.50522e+12 4.43761e+11 2.52356e+12 2.9117e+12 2.02793e+12 2.33704e+12 2.17714e+12 1 1.60867e+12 3.16815e+12 1.60941e+12 2.3654e+12 2.1765e+12 1.80567e+12 4.93783e+12 3.64767e+12 2.63976e+10 1.90407e+10 3.5266e+12 396745 396745 2.99597e+12 5.89833e+12 6.2837e+12 2.90583e+12 3.74367e+12 2.89805e+12 2.85504e+12 1.68773e+12 1.80838e+12 1.6071e+12 3.44292e+12 2.87974e+12 1 1 1.59759e+12 1.59555e+12 2.9199e+12 1.61962e+12 1.79008e+12 1.58027e+12 1.72731e+12 1.59783e+12 1.61006e+12 6.37839e+11 6.75227e+11 1 1 1.62675e+12 1.72603e+12 1.86613e+12 1 3.53995e+12 2.88419e+12 2.58476e+12 P-MAP4K1-2 1 1 2.51638e+10 1 1 8.97308e+08 1 8.97308e+08 1 1 1 1 1 1 2.58638e+10 1 1 1 1 2.58638e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 2.58638e+10 1 1 1 1 1 1 1 1 1 1.23302e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-ESR1-3 8.36395e+08 1 6.50465e+09 3.72896e+08 1 8.72375e+08 1 8.72375e+08 9.76546e+08 3.49598e+08 6.3752e+08 1.44548e+09 1 1.06495e+09 6.51875e+09 1 1.19492e+09 1 1 6.51556e+09 1.01138e+10 9.90845e+07 1 1 1 2.0167e+09 1.39486e+09 1 3.90898e+08 1 1 7.52589e+08 7.46655e+08 6.51556e+09 1 4.12335e+08 1 3.59274e+09 9.17558e+09 1.03079e+10 4.00754e+08 5.88468e+08 5.11297e+08 7.53261e+08 1.06324e+09 1 1.20168e+09 7.91484e+08 1.62104e+09 6.21058e+08 1.06354e+09 1.029e+09 3.98086e+08 1.27633e+08 1.53816e+06 992845 5.7812e+08 1 1 5.68803e+08 6.05467e+08 6.14744e+08 6.82558e+08 6.70136e+08 6.31456e+08 5.80286e+08 1.2385e+09 7.1386e+08 2.48686e+09 1.31701e+08 5.7272e+08 1 1 1.15826e+09 1.28382e+09 5.65019e+08 1.62797e+09 8.07217e+08 1.61798e+09 1.10713e+09 1.60212e+09 4.72241e+09 6.22088e+08 5.88736e+08 1 1 1.4801e+09 1.10849e+09 7.51937e+08 1 5.88062e+08 5.76986e+08 6.23573e+08 Active-CASP8-2 1 1 1 1 1 1 1 1 1 1 1 6.50497e+13 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6.18104e+13 1 1 1 1 1 1 1 1 1 1 1.33449e+13 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.15818e+13 4.8013e+13 6.50343e+13 1 1 1 1 1 1 1 1 1 1 6.57609e+13 1 1 1 1 1 1 1 P-PLCG 1 1 3.52191e+12 1 1 3.62654e+12 1 3.62654e+12 3.30128e+12 3.64039e+12 1 6.01157e+11 1 2.99644e+12 3.52188e+12 1 8.53863e+10 1 1 3.5219e+12 1 1 1 1 1 1 5.78031e+11 1 1 1 1 7.62157e+10 1 3.5219e+12 1 1 1 3.54432e+12 3.51889e+12 1 1 1 2.91213e+12 1.58701e+10 2.98899e+12 1 1.49848e+11 1 3.57148e+12 5.81478e+08 2.99549e+12 9.00309e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.56175e+12 1 3.65389e+12 1 1 1 1 8.5763e+10 1.23887e+11 1 7.57523e+10 3.58866e+12 3.56304e+12 3.43868e+11 3.56467e+12 3.54144e+12 1 1 1 1 4.01106e+11 3.45398e+11 1.52285e+11 1 1 1 1 G-ALPHA:GTP 2.4826e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.27372e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-TEC-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.39078e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.37713e+10 1 1 1 1 1 1 1 1 1 1 1 1 P-PTK2B-1 2.22926e+10 1 4.14318e+10 83900.3 1 4.1268e+10 1 4.1268e+10 4.12929e+10 4.12213e+10 9.46456e+07 4.13214e+10 1 4.12985e+10 4.14322e+10 1 4.07787e+10 1 1 4.14321e+10 1 592838 1 1 1 4.14323e+10 4.13164e+10 1 94275.2 1 1 3.15885e+10 1.05809e+06 4.14321e+10 1 104799 1 4.13093e+10 4.14192e+10 1 85960.3 229063 4.12761e+10 1.5829e+10 4.12983e+10 1 4.15631e+10 7.78981e+09 4.13328e+10 1.32027e+08 4.12983e+10 4.07465e+10 96086.8 19692.2 1 1 238330 1 1 1.65971e+06 234275 236430 293251 850901 288272 254560 4.13239e+10 2.44302e+06 4.13457e+10 21778.4 251663 1 1 4.07626e+10 4.14037e+10 227714 4.04641e+10 4.12759e+10 4.13106e+10 4.12789e+10 4.13313e+10 4.1381e+10 1 1 1 1 4.13094e+10 4.12795e+10 4.15072e+10 1 249712 259930 339950 P-MEK 1.21287e+11 1 1.27047e+11 2.08818e+10 1 1.26791e+11 1 1.26791e+11 1.26288e+11 1.27203e+11 5.56794e+10 1.27235e+11 1 1.26292e+11 1.27132e+11 1 1.25732e+11 1 1 1.2706e+11 1 6.85597e+10 1 1 1 1.27065e+11 1.26327e+11 1 1.96742e+10 1 1 1.20149e+11 8.10197e+10 1.2706e+11 1 2.37449e+10 1 1.27236e+11 1.45859e+11 1 2.04569e+10 3.87431e+10 1.27032e+11 1.17244e+11 1.26343e+11 1 1.25986e+11 1.11599e+11 1.27074e+11 6.18408e+10 1.26291e+11 1.2487e+11 1.94901e+10 5.58338e+09 2.99365e+08 2.66605e+08 3.94219e+10 809205 809205 9.32744e+10 3.73376e+10 3.7097e+10 4.4994e+10 7.6229e+10 4.45373e+10 4.19238e+10 1.26264e+11 9.71192e+10 1.27025e+11 5.71641e+09 4.15676e+10 1 1 1.25836e+11 1.26739e+11 3.85837e+10 1.36423e+11 1.27955e+11 1.26117e+11 1.25577e+11 1.26239e+11 1.2712e+11 1 1 1 1 1.26532e+11 1.25192e+11 1.25558e+11 1 4.04349e+10 4.2416e+10 4.87613e+10 SKIL-4 1.70006e+06 2.20491e+07 320983 1.94469e+06 1 410290 1 410290 266529 274253 2.8031e+06 388124 1 285810 320993 1 822928 1 1 320951 819406 3.06106e+06 1 1 1 324021 406722 1 1.49565e+06 1 1 2.38676e+06 3.20721e+06 320951 1 2.00923e+06 1 242737 338478 2.27468e+06 1.83169e+06 2.38129e+06 54679.6 2.17129e+06 285901 1 610637 2.39226e+06 344074 2.64899e+06 285946 8.26441e+08 1.36138e+06 620736 4760.63 3618.94 2.29359e+06 1 1 3.29916e+06 1.98911e+06 1.91101e+06 2.5552e+06 3.15568e+06 2.54206e+06 2.52688e+06 333178 3.18701e+06 336210 518908 2.48753e+06 1 1 822503 665623 2.37653e+06 893772 374978 362614 684760 344317 478528 2.92809e+06 2.91623e+06 1 1 520731 683967 643298 1 2.31457e+06 2.51186e+06 2.64637e+06 P-DAPK1-1 1.43462e+10 1 1.51591e+10 1.06281e+10 1 1.48321e+10 1 1.48321e+10 1.4859e+10 1.42094e+10 1.25245e+10 1.50366e+10 1 1.48851e+10 1.51569e+10 1 1.50096e+10 1 1 1.51564e+10 1.03947e+10 1.37567e+10 1 1 1 1.51991e+10 1.50254e+10 1 1.99926e+10 1 1 1.46359e+10 1.41196e+10 1.51564e+10 1 1.10008e+10 1 1.11151e+10 1.53568e+10 1.03949e+10 1.06672e+10 1.20175e+10 1.4841e+10 1.43079e+10 1.48849e+10 1 1.50172e+10 1.37083e+10 1.50324e+10 1.33171e+10 1.48844e+10 1.48476e+10 1.88901e+10 1.7173e+10 1.11537e+09 9.92225e+08 1.18097e+10 4.36545e+06 4.36545e+06 1.34583e+10 1.11004e+10 1.10579e+10 1.23337e+10 1.28179e+10 1.23173e+10 1.21965e+10 1.49205e+10 1.43761e+10 1.50486e+10 7.12338e+09 1.21809e+10 1 1 1.5019e+10 1.50526e+10 1.20034e+10 1.51098e+10 1.47975e+10 1.50104e+10 1.48918e+10 1.50242e+10 1.52172e+10 1.2065e+10 1.20413e+10 1 1 1.50107e+10 1.48847e+10 1.47377e+10 1 1.18569e+10 1.22202e+10 1.2682e+10 P-PDK 1 1 2.31516e+10 3.5342e+07 1 2.11525e+10 1 2.11525e+10 2.2063e+10 2.35669e+10 3.72983e+08 5.45893e+09 1 2.07301e+10 2.32117e+10 1 9.23077e+08 1 1 2.32148e+10 1 2.08698e+08 1 1 1 1 4.48083e+09 1 9.93354e+07 1 1 1.64612e+09 9.34998e+08 2.32148e+10 1 6.60837e+07 1 2.18189e+10 2.16866e+10 1 5.04032e+07 2.28386e+08 1.49113e+10 3.46695e+08 2.06986e+10 1 1.57287e+09 1 2.13589e+10 1.06885e+07 2.07202e+10 8.80625e+08 1.1645e+08 1.54253e+07 1 1 2.27466e+08 1 1 1.14603e+09 3.0904e+08 3.34584e+08 3.0364e+08 9.21373e+08 2.98257e+08 2.14483e+08 2.19855e+10 8.84214e+08 2.2285e+10 1.8554e+07 2.13841e+08 1 1 9.53342e+08 1.29204e+09 2.2943e+08 8.1491e+08 2.16678e+10 2.16287e+10 3.26638e+09 2.1377e+10 2.15289e+10 1 1 1 1 3.94565e+09 3.31691e+09 1.68144e+09 1 2.57154e+08 2.22575e+08 4.34242e+08 P-IRS1-1 2.27913e+07 1 1 4.36767e+06 1 1 1 1 1 1 4.1115e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6.79835e+07 1 1 1 1 1 1 1.02614e+07 1 4.3946e+07 1 1 1 1 1 1 1 1 1 1.18956e+07 1.27504e+07 4.29306e+06 1 1 7.53782e+07 1.05337e+07 1.35854e+10 1.09747e+10 5.71672e+07 1 1 3.67989e+08 1 1 1 2.19214e+08 1 5.91173e+07 1 7.74143e+08 1 5.63553e+06 6.00492e+07 1 1 6.30884e+08 1 1 1 1 1 1 6.54738e+06 1 1 1 1 1 1 1 1 1 1 1 1 Evading_apoptosis 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.97598e+11 3.01558e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.94874e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-TYK2-1:P-JAK1-1:IL10-1:IL10RA-1:IL10RB-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.06481e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-STAT4-1 1 1 1 2.3539e+08 1 1 1 1 1 1 2.14763e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.35546e+08 3.35546e+08 1 3.40605e+09 3.57472e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.30488e+09 1 1 P-SHC1-3:GRB2-1:SOS1-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.59232e+07 1 1 1 1 1 1 1.32427e+07 1 1 1 1 9.63461e+06 4.70899e+07 1 1 1 1 1 1 1 1 1 1 4.76536e+07 1 3.89272e+09 3.48053e+09 3.92944e+07 8.00321e+06 8.00321e+06 1 1 1 6.1508e+07 1 5.86967e+07 3.97911e+07 1 8.44363e+08 1 3.33324e+06 4.031e+07 1 1 1 1 4.73991e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.21713e+07 1.04797e+08 IL13-4:IL13RA1-1:IL4R-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.07732e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-PI3K:P-JAK1-1:P-JAK3-1 1 1 1 2.9632e+07 1 1 1 1 1 1 2.85882e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 5.80272e+08 6.30389e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.87566e+08 1 1 IL2-1:IL2RA-1:IL2RB-2:IL2RG-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.62592e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-PI3K:P-JAK2-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.04941e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7.10592e+08 1 6.76981e+08 1 1 1 1 3.77205e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-STAT6-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7.56321e+08 1 1 1 2.98736e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DiP-RPS6KB1-5 3.15644e+07 1 1.01319e+10 2.45304e+07 1 8.62657e+09 1 8.62657e+09 8.09723e+09 8.59446e+09 2.02988e+08 2.70171e+09 1 8.04804e+09 1.01854e+10 1 5.52893e+08 1 1 1.01867e+10 2.69231e+06 2.12224e+08 1 1 1 4.1698e+07 2.24341e+09 1 3.32066e+07 1 1 8.6149e+08 5.57045e+08 1.01867e+10 1 3.40481e+07 1 8.57998e+09 8.78087e+09 2.71212e+06 2.59248e+07 9.88288e+07 7.42005e+09 2.23387e+08 8.04281e+09 1 8.92555e+08 2.55581e+07 8.67599e+09 2.60188e+07 8.05101e+09 4.28943e+08 3.04892e+07 2.69486e+06 24.1528 13.8762 1.01254e+08 1 1 8.89378e+08 1.02401e+08 1.04395e+08 1.37188e+08 5.14875e+08 1.34119e+08 1.0887e+08 8.89707e+09 8.9772e+08 9.85166e+09 2.12033e+06 1.06985e+08 1 1 5.92476e+08 7.20968e+08 9.83535e+07 4.93118e+08 8.86639e+09 8.84631e+09 1.94133e+09 8.68686e+09 8.73137e+09 6.38322e+06 8.1463e+06 1 1 2.29343e+09 1.97074e+09 1.036e+09 1 1.09732e+08 1.11475e+08 1.71345e+08 IL6-1:IL6R-1:IL6ST-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.55124e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 MTOR-1:MAPKAP1-4:MLST8-1:PRR5-8:RICTOR-1 1 1 6.95566e+06 12194.5 1 6.10264e+06 1 6.10264e+06 6.73099e+06 7.56273e+06 111679 1.57995e+06 1 6.23298e+06 6.95296e+06 1 273384 1 1 6.95485e+06 1 76155.8 1 1 1 1 1.30737e+06 1 28718.7 1 1 468636 277242 6.95485e+06 1 20713.4 1 6.51967e+06 6.45596e+06 1 16068.5 66414.8 4.57052e+06 102657 6.22376e+06 1 465130 1 6.08173e+06 4034.86 6.22949e+06 243650 33110.7 4632.56 1 1 67255.9 1 1 365134 87319.9 93720.2 87949.7 268153 86409.1 64408.8 6.8431e+06 314796 6.81619e+06 5550.45 64135.3 1 1 287341 379172 66588.2 241380 6.34067e+06 6.36228e+06 899697 6.10371e+06 6.34497e+06 1 1 1 1 1.10057e+06 913203 507644 1 74982 66648.6 120909 P-IRS2-1 1 1 1 1.03749e+07 1 1 1 1 1 1 6.1269e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.21052e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.56459e+08 1 1 1 2.47464e+08 1 1 1 5.33635e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-FYN-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.14126e+10 7.17296e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.92079e+10 1 1 1 1 1 1 1 1 1.54194e+09 1.87171e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-AMPKA:AMPKG:AMPKB 1.23359e+07 1 1 1 1 1 1 1 1 1 1 1 1.30957e+11 1 1 1 1 1 1 1 1 9.24721e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 836334 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6.27607e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-SHC1-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 5.86572e+08 1 1 1 1 1 1 1.99026e+08 1 1 1 1 1.35559e+08 7.33876e+08 1 1 1 1 1 1 1 1 1 1 6.52327e+08 1 9.07462e+10 7.68456e+10 4.92931e+08 1.17825e+08 1.17825e+08 1 1 1 9.29938e+08 1 8.85511e+08 5.1045e+08 1 1.42186e+10 1 4.90728e+07 5.18517e+08 1 1 1 1 7.48479e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 5.48809e+08 2.1277e+09 P-TBK1-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.26749e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.29295e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-MAP3K14-1 1 1 2.52549e+10 1.42464e+09 1 2.3667e+10 1 2.3667e+10 2.20683e+10 2.20939e+10 5.64157e+09 1.89911e+10 1 2.26549e+10 2.52876e+10 1 1.08526e+10 1 1 2.52877e+10 1 6.49806e+09 1 1 1 1 1.8128e+10 1 1.50211e+09 1 1 1.06692e+10 1.0358e+10 2.52877e+10 1 1.66116e+09 1 2.33451e+10 2.35297e+10 1 1.39188e+09 3.35996e+09 2.3711e+10 5.40944e+09 2.26598e+10 1 1.31598e+10 1 2.35693e+10 5.72336e+08 2.26665e+10 7.81022e+09 1.57855e+09 3.42978e+08 1 1 3.54518e+09 1 1 1.35179e+10 3.61548e+09 3.6584e+09 4.34012e+09 9.75101e+09 4.28092e+09 3.79634e+09 2.35752e+10 1.84989e+10 2.5174e+10 3.91244e+08 3.62071e+09 1 6.51642e+08 1.09661e+10 1.17879e+10 3.34571e+09 1.0157e+10 2.3755e+10 2.37566e+10 2.04195e+10 2.35895e+10 2.3512e+10 1 1 1 1 2.08252e+10 2.046e+10 1.42975e+10 1 3.67624e+09 3.71271e+09 4.46891e+09 P-DOK1-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 5.8763e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-PI3K:P-NTRK3-4:NTF3-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 5.88386e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Active-PI3K:P-JAK1-1:P-TYK2-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.67413e+08 1 1 1 1 1 1 8.35997e+07 1 1 1 1 1 4.94009e+08 1 1 1 1 1 1 1 1 1 1 5.1068e+08 1 1 1 3.94683e+08 1 1 1 1 1 1 1 1 3.51989e+08 1 1 1 1 3.57345e+08 1 1 1 1 4.78365e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.61332e+08 1.3496e+09 P-VAV 1 1 1 1 1 1 1 1 2.34284e+11 2.36574e+11 5.3771e+08 1 1 2.03848e+11 1 1 8.14488e+09 1 1 1 1 1.39168e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.97777e+11 1 2.03523e+11 1 1 1 1.07959e+11 1 2.03846e+11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2.19906e+11 1 1 1 1 1 1 1 7.24903e+09 1.92518e+10 1.03708e+10 1 1.07269e+11 1 1 1 1 1 1 1 1 1 1 1 1 P-ABL1-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.02221e+08 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8.97844e+07 4.13929e+07 1.85146e+07 1 1 1 1 1 1 1 1 1 1 1 1 1 1 P-TNK2-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.72795e+09 1 1 1 1 1 1 1 1 1 1.54194e+09 1.87171e+09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 RAF1-1:KRAS-2:GTP 7.86568e+07 1 1.27242e+08 32373.4 1 1.21576e+08 1 1.21576e+08 1.29715e+08 1.29916e+08 62934.1 1.1767e+08 1 1.29154e+08 1.27352e+08 1 1.08978e+08 1 1 1.27352e+08 1 101167 1 1 1 1.08065e+08 1.17044e+08 1 116881 1 1 6.00475e+07 301493 1.27352e+08 1 35208.3 1 1.33146e+08 6.25726e+07 1 27863.6 103955 1.29469e+08 5.57864e+07 1.29109e+08 1 1.12391e+08 3.91851e+07 1.20394e+08 2.67176e+06 1.29158e+08 1.06892e+08 108745 251.475 8.21981e+06 7.35979e+06 102083 19868.7 19868.7 137149 59764.2 62436.1 138555 89152.8 132906 105703 1.21333e+08 1.00736e+07 1.2386e+08 8554.49 105829 1 1 1.08975e+08 1.11124e+08 103216 8.06524e+07 1.14722e+08 1.21422e+08 1.17011e+08 1.20413e+08 1.2105e+08 1 1 1 1 1.18858e+08 1.17081e+08 1.12739e+08 1 60457.1 109833 177652 P-NEK3-5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.39078e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.37713e+10 1 1 1 1 1 1 1 1 1 1 1 1 P-SMAD2_3:SMAD4-1 2.43494e+06 3.4369e+07 496064 2.92187e+06 1 572046 1 572046 372078 381066 4.43293e+06 567772 1 412495 496072 1 1.12306e+06 1 1 496010 1.24639e+06 4.72857e+06 1 1 1 498293 587147 1 2.35695e+06 1 1 3.04976e+06 5.00504e+06 496010 1 3.05231e+06 1 415087 515084 3.45302e+06 2.78166e+06 3.73338e+06 78138.3 3.0946e+06 412769 1 844069 3.50356e+06 519130 4.1693e+06 412874 1.1576e+06 2.22998e+06 934515 8809.87 6809.1 3.68311e+06 1 1 5.14404e+06 3.36288e+06 3.28394e+06 4.04085e+06 4.97041e+06 4.02074e+06 3.96084e+06 512174 5.06333e+06 512516 827937 3.89762e+06 1 1 1.12251e+06 916603 3.72519e+06 1.22018e+06 547290 535730 855884 520439 751072 4.59129e+06 4.57092e+06 1 1 696047 853868 872815 1 3.71433e+06 3.93472e+06 4.09744e+06 P-SMAD2_3:STRAP-1 2.15987e+09 1.2326e+10 8.66846e+08 1.77618e+09 1 9.21519e+08 1 9.21519e+08 8.81488e+08 8.80758e+08 2.68286e+09 9.30929e+08 1 8.82645e+08 8.66998e+08 1 1.37035e+09 1 1 8.66874e+08 8.89801e+08 3.03459e+09 1 1 1 9.0562e+08 9.4645e+08 1 1.45777e+09 1 1 2.36681e+09 3.06276e+09 8.66874e+08 1 1.86496e+09 1 7.11542e+08 9.03358e+08 2.39981e+09 1.69628e+09 2.29224e+09 8.93564e+08 2.41397e+09 8.82555e+08 1 1.1668e+09 2.60615e+09 8.83543e+08 2.66634e+09 8.82503e+08 1.40936e+09 1.33303e+09 5.38136e+08 4.29568e+06 3.33393e+06 2.23676e+09 69.756 69.756 3.09065e+09 1.98681e+09 1.93032e+09 2.44416e+09 2.9606e+09 2.432e+09 2.40297e+09 8.69087e+08 3.07417e+09 8.74701e+08 4.68961e+08 2.39034e+09 1 1 1.36927e+09 1.22444e+09 2.28722e+09 1.44984e+09 9.00411e+08 8.92301e+08 1.15807e+09 8.81973e+08 1.16562e+09 2.91582e+09 2.91583e+09 1 1 1.04453e+09 1.15624e+09 1.18106e+09 1 2.26097e+09 2.41423e+09 2.57095e+09 TGFB3-1_dimer:TGFBR_dimer 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.96074e+10 1 1 1 1 1 1 1 1 1 CD36-1:THBS1-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.53383e+10 1 1 1 1 1 1 1 1 Active-CASP10-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.09318e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.29815e+10 1 1 1 1 1 1 1 Sustained_angiogenesis 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8.97735e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.11705e+10 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.18653e+10 1 1.1215e+10 1 1 1 1 Active-PI3K:P-FLT1-1_dimer:VEGFB-2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1.55549e+10 1 1 1 1 1 Active-PI3K:P-KDR-1_dimer:VEGFC-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3.21202e+09 1 1 1 1 WNT:WIF1-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4.45479e+12 1 1 1 RRAS-1:GTP 1.00722e+09 1 1.32515e+09 10705.4 1 1.31916e+09 1 1.31916e+09 1.32309e+09 1.33716e+09 800173 1.32287e+09 1 1.32351e+09 1.37783e+09 1 1.32399e+09 1 1 1.32519e+09 1 72976.4 1 1 1 1.32299e+09 1.32327e+09 1 9583.9 1 1 1.09169e+09 6.43357e+06 1.32519e+09 1 12467 1 1.37448e+09 1.3649e+09 1 10342.1 23342.7 1.32952e+09 7.5556e+08 1.32357e+09 1 1.32814e+09 4.51419e+08 1.32285e+09 1.05991e+07 1.32351e+09 1.32761e+09 9269.09 2369.33 1 1 23364.4 1 1 160360 1.28118e+06 1.35929e+06 29042.9 77497.2 28570 26389.4 1.32262e+09 303225 1.32299e+09 2412.98 26029.8 1 1 1.32371e+09 1.3272e+09 23195.6 1.32175e+09 1.32343e+09 1.32347e+09 1.33275e+09 1.32285e+09 1.32337e+09 1 1 1 1 1.32562e+09 1.33281e+09 1.32918e+09 1 1.21581e+06 26843.5 33694 P-AR-1 6.63517e+10 1 3.83092e+12 3.31514e+10 1 6.25227e+11 1 6.25227e+11 7.15966e+11 8.69967e+11 5.3037e+10 4.78891e+11 1 1.12839e+12 3.86388e+12 1 1.47129e+11 1 1 3.86399e+12 2.15455e+10 6.58849e+10 1 1 1 7.83584e+10 4.64274e+11 1 3.10629e+10 1 1 8.60547e+10 8.22685e+10 3.86399e+12 1 3.53202e+10 1 1.36174e+12 1.56351e+12 2.15455e+10 3.25958e+10 4.45497e+10 9.74389e+11 7.06928e+10 1.12606e+12 1 1.95576e+11 6.11282e+10 5.53186e+11 5.10417e+10 1.1259e+12 9.0378e+10 2.99808e+10 1.45209e+10 3.01758e+08 2.37861e+08 4.37302e+10 4621.72 4621.72 8.66398e+10 4.12426e+10 4.0908e+10 4.84203e+10 6.6802e+10 4.81566e+10 4.65337e+10 1.3632e+12 4.1683e+11 1.81355e+12 1.42428e+10 4.60457e+10 1 1 1.46456e+11 1.74804e+11 4.4472e+10 1.14328e+11 7.19671e+11 8.70749e+11 2.59825e+11 5.51161e+11 1.13107e+12 3.11508e+10 3.1151e+10 1 1 3.64974e+11 2.61253e+11 1.7874e+11 1 4.43702e+10 4.65263e+10 5.12991e+10 CCND3-1 7.11026e+10 1 7.19649e+10 1.9617e+10 1 7.23561e+10 1 7.23561e+10 5.95089e+11 5.60794e+11 3.8204e+10 7.24378e+10 1 5.15626e+11 7.19966e+10 1 7.19345e+10 1 1 7.19761e+10 1 5.59609e+10 1 1 1 7.59971e+10 7.20361e+10 1 1.32496e+10 1 1 6.67102e+10 5.69071e+10 7.19761e+10 1 2.10584e+10 1 7.2359e+10 7.62286e+10 1 1.76139e+10 2.90669e+10 5.08034e+11 6.7966e+10 5.15305e+11 1 7.2009e+10 6.35091e+10 7.44006e+10 4.11313e+10 5.15803e+11 7.22022e+10 1.03874e+10 2.72011e+09 6.27379e+06 4.71787e+06 2.57528e+10 104.545 104.545 6.04454e+10 1.85804e+10 1.71763e+10 3.15344e+10 4.74781e+10 3.11495e+10 3.10954e+10 7.35761e+10 6.65399e+10 7.21661e+10 2.01242e+09 3.16735e+10 1 1 7.13945e+10 7.18161e+10 2.89745e+10 7.45684e+10 7.51391e+10 7.21799e+10 1.15254e+11 7.45844e+10 7.15309e+10 1 1 1 1 1.20037e+11 1.15674e+11 7.27004e+10 1 2.65849e+10 3.2146e+10 3.80542e+10 C.7 Validation of miRNA Effect on Ligand component_name control_BDNF control_BDNF_mir control_EGF control_EGF_mir control_FASLG control_FASLG_mir control_GH1 control_GH1_mir control_IGF1 control_IGF1_mir control_TGFB1 control_TGFB1_mir control_VEGFA control_VEGFA_mir Active-CASP2-1[179697] 4.63918e+08 1.50296e+03 1 1 1 1 1 1 1 1 1 1 1 1 P-ERK[153212] 1.64201e+06 217669 2.5835e+06 75.8084 1 1 1.79228e+06 18516.9 947.407 173.374 5.20282e+07 147.588 1.59474e+06 794.812 Active-CASP8-2[178987] 1.44461e+09 1.43064e+04 1 1 1.65884e+08 274664 1 1 1 1 1 1 1 1 P-TEC-1[182526] 1 1 1 1 1 1 1.16854e+09 3.97339e+03 1 1 1 1 1 1 P-IRS1-1[158894] 1 1 1 1 1 1 1.03025e+07 3.34151e+04 3.33113e+08 8.93993e+04 1 1 1 1 P-SMAD2_3:SMAD4-1[162251] 1 1 1 1 1 1 1 1 1 1 2.87059e+06 30.6232 1 1 Sustained_angiogenesis[153170] 1 1 1 1 1 1 1 1 1 1 1 1 4.29891e+09 1.43934e+04 C.9 Drug Responses to Imatinib and Temsirolimus Imatinib Response / Cell Line MDA-MB-468 T-47D BT-549 HS 578T MDA-MB-231/ATCC MCF7 DU-145 PC-3 UO-31 TK-10 SN12C RXF-393 CAKI-1 ACHN A498 786-0 SK-OV-3 NCI/ADR-RES OVCAR-8 OVCAR-5 OVCAR-4 OVCAR-3 IGROV1 UACC-62 UACC-257 SK-MEL-5 SK-MEL-28 SK-MEL-2 MDA-N MDA-MB-435 M14 MALME-3M LOX IMVI U251 SNB-19 SNB-75 SF-539 SF-295 SF-268 SW-620 KM12 HT29 HCT-15 HCT-116 HCC-2998 COLO 205 NCI-H522 NCI-H460 NCI-H322M NCI-H23 NCI-H226 HOP-92 HOP-62 EKVX A549/ATCC SR RPMI-8226 MOLT-4 K-562 HL-60(TB) CCRF-CEM Experimental Data 0 4.7 4.79 4.84 4.73 4.74 4.73 4.67 4.65 4.57 4.48 4.82 4.47 4.6 4.66 4.8 4.54 4.64 4.56 6.24 4.7 4.47 4.67 4.72 4.68 4.92 4.84 4.6 0 4.75 4.71 4.79 4.74 4.74 4.41 4.69 4.98 4.7 4.58 4.63 4.73 5.4 4.7 4.9 4.67 4.75 4.78 4.79 4.64 4.82 4.74 4.87 4.67 4.58 4.61 5.15 5.22 5.29 7.63 4.87 4.77 Prediction Data 0 4.7 3.986204 4 4 4 4 4.67 4 3.998672 4 4 3.907036 4 4 4 4 4 4 4 3.999976 4 4 4 4 4 3.991564 3.99994 0 4 4 4.69636 4 4 4 4 4 4 4 4 4.0294 3.998072 4 4 4 4.42376 3.975184 4.08476 4 3.999988 4 4 4 4 3.986204 4 4 4 4 3.999996 3.999192 Temsirolimus Response / Cell Line MDA-MB-468 T-47D BT-549 HS 578T MDA-MB-231/ATCC MCF7 DU-145 PC-3 UO-31 TK-10 SN12C RXF-393 CAKI-1 ACHN A498 786-0 SK-OV-3 NCI/ADR-RES OVCAR-8 OVCAR-5 OVCAR-4 OVCAR-3 IGROV1 UACC-62 UACC-257 SK-MEL-5 SK-MEL-28 SK-MEL-2 MDA-N MDA-MB-435 M14 MALME-3M LOX IMVI U251 SNB-19 SNB-75 SF-539 SF-295 SF-268 SW-620 KM12 HT29 HCT-15 HCT-116 HCC-2998 COLO 205 NCI-H522 NCI-H460 NCI-H322M NCI-H23 NCI-H226 HOP-92 HOP-62 EKVX A549/ATCC SR RPMI-8226 MOLT-4 K-562 HL-60(TB) CCRF-CEM Experimental Data 0 8 8 8 5.58 8 7.42 7.31 8 6.45 6.3 6.9 6.66 8 0 8 5.71 5.99 7.84 4.23 8 5.75 8 8 5.7 5.73 6.73 6.95 5.4 5.6 4.8 8 8 6.87 6.82 8 8 8 5.52 5.37 5.66 6.74 7.65 5.49 5.74 5.4 6.92 0 5.24 5.87 7.73 5.8 7.69 8 6.02 8 7.61 8 7.64 5.56 8 Prediction Data 0 8 7.62699 6.14491 8.75842 8.8974 6.02467 7.31 6.75565 5.99302 7.67282 7.06028 7.31378 8.16609 0 7.40247 6.66601 7.21431 6.92079 8.15888 6.72265 7.02089 5.99042 5.20735 6.81747 6.18797 6.95477 7.43961 5.4 6.00571 6.57916 8.95394 6.80875 6.90961 6.49256 7.38446 7.08425 6.1149 7.22103 7.10998 6.8122 8.21632 6.47956 5.81386 7.59643 6.17804 6.0728 0 8.18155 6.98005 8.54561 7.57108 9.36999 8.89535 7.62699 8.79503 7.16663 8.20499 5.71108 6.73763 7.61929 C.2 miRNA Target Validation Reference from miRNA_EGF Model miRNA Target Gene Pubmed 151162,MI0003558,mir-553 DICER1, ENSG00000100697 16505370 150975,MI0000778,mir-370 MAP3K8, ENSG00000107968 17621267 151213,MI0003620,mir-607 DICER1, ENSG00000100697 16505370 151264,MI0003681,mir-657 DICER1, ENSG00000100697 16505370 150743,MI0000063,let-7b EGFR, ENSG00000146648 18668040 JUN, ENSG00000177606 18668040 PTEN, ENSG00000171862 18704095 MYC, ENSG00000136997 17942906 MAPK14, ENSG00000112062 15131085,15806104 150797,MI0000089,mir-31 PTEN, ENSG00000171862 19175831 MYC, ENSG00000136997 18451220 150807,MI0000095,mir-93 CDKN1, ENSG00000111276 19153141 CDKN1, ENSG00000124762 18212054,19153141,18328430 151211,MI0003618,mir-605 DICER1, ENSG00000100697 16505370 151212,MI0003619,mir-606 DICER1, ENSG00000100697 16505370 151242,MI0003651,mir-636 DICER1, ENSG00000100697 16505370 150894,MI0000489,mir-195 TP53, ENSG00000141510 18677302 PTEN, ENSG00000171862 19175831 MYC, ENSG00000136997 18451220 CDKN1, ENSG00000124762 19823043 151349,MI0006341,mir-1208 MYC, ENSG00000136997 18314482 151166,MI0003563,mir-557 DICER1, ENSG00000100697 16505370 151255,MI0003663,mir-648 DICER1, ENSG00000100697 16505370 150883,MI0000483,mir-186 FOXO, ENSG00000150907 20028871 150811,MI0000101,mir-99a CREB1, ENSG00000118260 19897480 DICER1, ENSG00000100697 19416898 MYC, ENSG00000136997 18451220 150988,MI0000786,mir-378 PTEN, ENSG00000171862 19175831 RNASEN, ENSG00000113360 18550634 FOS, ENSG00000170345 16236258 151346,MI0006338,mir-1205 MYC, ENSG00000136997 18314482 151250,MI0003658,mir-643 DICER1, ENSG00000100697 16505370 151044,MI0003188,mir-503 DICER1, ENSG00000100697 19799966 150762,MI0000438,mir-15b BAD, ENSG00000002330 18449891 MKK4/7, ENSG00000065559 19861690 150776,MI0000439,mir-23b DICER1, ENSG00000100697 18832437 MYC, ENSG00000136997 19219026,20086171 NF-KB, ENSG00000173039 20144951,19997496 151345,MI0006337,mir-1204 MYC, ENSG00000136997 18194563,18314482 151208,MI0003615,mir-602 DICER1, ENSG00000100697 16505370 151195,MI0003597,mir-588 DICER1, ENSG00000100697 16505370 151175,MI0003574,mir-568 DICER1, ENSG00000100697 16505370 151237,MI0003645,mir-631 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 16505370,19138993 DGCR8, ENSG00000128191 19138993 151268,MI0003669,mir-661 DICER1, ENSG00000100697 16505370 151253,MI0003661,mir-646 DICER1, ENSG00000100697 16505370 151223,MI0003631,mir-617 DICER1, ENSG00000100697 16505370 151245,MI0003654,mir-639 DICER1, ENSG00000100697 16505370 151077,MI0003156,mir-518b IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 19493678,18552348 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 18802929,18314482,19530237 FOS, ENSG00000170345 16236258 150877,MI0000271,mir-181c MYC, ENSG00000136997 18451220 AKT, ENSG00000142208 19699171 150750,MI0000434,let-7i NF-KB, ENSG00000109320 19903813 150810,MI0000100,mir-98 PTEN, ENSG00000171862 19175697 MYC, ENSG00000136997 19528081,18413726,17942906 151233,MI0003641,mir-627 DICER1, ENSG00000100697 16505370 150927,MI0000300,mir-223 DICER1, ENSG00000100697 19059913 DGCR8, ENSG00000128191 19059913 150982,MI0000783,mir-375 PDPK1, ENSG00000140992 18591395 MAPK14, ENSG00000112062 15806104 151182,MI0003582,mir-575 DICER1, ENSG00000100697 16505370 150953,MI0000824,mir-325 MYC, ENSG00000136997 18451220 151001,MI0003685,mir-421 PTEN, ENSG00000171862 19175831 DICER1, ENSG00000100697 16505370 MYC, ENSG00000136997 20080624 151173,MI0003572,mir-566 DICER1, ENSG00000100697 16505370 151243,MI0003652,mir-637 DICER1, ENSG00000100697 16505370 151206,MI0003613,mir-600 DICER1, ENSG00000100697 16505370 150866,MI0000479,mir-150 MAP3K8, ENSG00000107968 18006822 IKK, ENSG00000143466 19177201 CDKN1, ENSG00000111276 19264517 MYC, ENSG00000136997 18066065 150871,MI0000480,mir-154 MYC, ENSG00000136997 18451220 150809,MI0000098,mir-96 MTOR, ENSG00000198793 20018759 FOXO, ENSG00000150907 20028871,19574223 150898,MI0000239,mir-197 MYC, ENSG00000136997 18451220 151224,MI0003632,mir-618 DICER1, ENSG00000100697 16505370 151011,MI0001648,mir-449a CDKN1, ENSG00000111276 19252524 151143,MI0006402,mir-548o IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151159,MI0003556,mir-551a DICER1, ENSG00000100697 16505370 150784,MI0000085,mir-27a TP53, ENSG00000141510 19950226 PTEN, ENSG00000171862 16762633 ATF1, ENSG00000123268 19950226 CDKN1, ENSG00000124762 19950226 FOXO, ENSG00000150907 19574223 151266,MI0003683,mir-659 DICER1, ENSG00000100697 16505370 151142,MI0006399,mir-548n IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 19493678,18552348,20097187 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 18314482,18802929,19530237 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150749,MI0000433,let-7g MYC, ENSG00000136997 19153603,19492978,18413726 151246,MI0003655,mir-640 DICER1, ENSG00000100697 16505370 151205,MI0003611,mir-599 DICER1, ENSG00000100697 16505370 150765,MI0000071,mir-17 MTOR, ENSG00000198793 20022054 CD28, ENSG00000178562 20148420 MEK, ENSG00000169032 15944709 ELK1, ENSG00000126767 20003307 IKK, ENSG00000143466 19177201 CREB1, ENSG00000118260 20003307 TP53, ENSG00000141510 16878133,18521848,19477219,20014148,19347736,19158830 YWHAB, ENSG00000166913 15944709 PTEN, ENSG00000171862 19175831,19175697,19660235,18429962,18327259,18765795 RNASEN, ENSG00000113360 17322031,19706389,17558416,18550634 DICER1, ENSG00000100697 18779589,18329371,18320056,18398510 MYC, ENSG00000136997 17325905,19806017,19477219,17943719,15944709,17284533,20008931,18941111,19064005,18493594,20014148,19492978,19351822,17942906,18779589,19435428,17765889,16096373,19706389,19116113,18836483,18451220,18632605,19672269,15944707,19690137,18066065,18327259,18583030,17624268,18922889,17608773,17438130,16878133,19066217 CDKN1, ENSG00000124762 19782699,18941111,19660235,18922889,20089119 MAPK14, ENSG00000112062 19559694 NF-KB, ENSG00000173039 20144951,15944709 151087,MI0003145,mir-519e IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151209,MI0003616,mir-603 DICER1, ENSG00000100697 16505370 151154,MI0003679,mir-549 DICER1, ENSG00000100697 16505370 150926,MI0000299,mir-222 ERK, ENSG00000100030 19438724 CDKN1, ENSG00000111276 17627278,19264608,18708351,19150885,19107213,19424584,19153141,18413744,19351827,17914108,17721077,18417445,17569667,19273599 PIK3CA, ENSG00000121879 18790736,18708351 TP53, ENSG00000141510 18708351,18790736 PTEN, ENSG00000171862 19962668,20021821 RNASEN, ENSG00000113360 18550634,17540974 DICER1, ENSG00000100697 19520829 MYC, ENSG00000136997 18777135 AKT, ENSG00000142208 18708351,18790736 CDKN1, ENSG00000124762 19153141 151222,MI0003629,mir-616 DICER1, ENSG00000100697 16505370 151185,MI0003585,mir-578 DICER1, ENSG00000100697 16505370 151200,MI0003605,mir-593 DICER1, ENSG00000100697 16505370 151199,MI0003604,mir-592 DICER1, ENSG00000100697 16505370 150865,MI0000478,mir-149 TP53, ENSG00000141510 19950226 MYC, ENSG00000136997 19082544,18451220 ATF1, ENSG00000123268 19950226 CDKN1, ENSG00000124762 19950226 FOS, ENSG00000170345 16236258 150761,MI0000069,mir-15a ERK, ENSG00000100030 19109256 MDM2, ENSG00000135679 19723889 BAD, ENSG00000002330 18449891 JUN, ENSG00000177606 18362358 TP53, ENSG00000141510 17554199,19347736 DICER1, ENSG00000100697 19416898 MYC, ENSG00000136997 19591824,18066065,19211792,17624268 MAPK14, ENSG00000112062 15131085 151163,MI0003559,mir-554 DICER1, ENSG00000100697 16505370 150759,MI0000266,mir-10a MAP3K8, ENSG00000107968 18006822 MEK, ENSG00000169032 17330104 150802,MI0000742,mir-34b MDM2, ENSG00000135679 18451145 CREB1, ENSG00000118260 19258499 TP53, ENSG00000141510 18941118,18451145,17554337 MYC, ENSG00000136997 18802929,18768788,18451220 150930,MI0005775,mir-297 RNASEN, ENSG00000113360 17322031 151187,MI0003587,mir-580 DICER1, ENSG00000100697 16505370 150773,MI0000077,mir-21 PKC, ENSG00000171132 19633292 MTOR, ENSG00000198793 19072831,20018759 ELK1, ENSG00000126767 20003307 EGFR, ENSG00000146648 19493678,20048743,20113523,19047896,19597153 IKK, ENSG00000143466 19177201 CREB1, ENSG00000118260 20003307 CDKN1, ENSG00000111276 18708351 JUN, ENSG00000177606 18384814 PIK3CA, ENSG00000121879 18708351,18335499,19047896 CASP9, ENSG00000132906 18841558 TP53, ENSG00000141510 19047896,18335499,18708351 PTEN, ENSG00000171862 19473551,19175697,19264808,19730150,19212625,20092645,18335499,19641183,19711427,19509158,19072831,20048743,19080492,19450585,16762633,17681183,20113523,19906824,19672202,20153722,17478730,19147652,19175831,18841558,19213759,18850008,18460397 RNASEN, ENSG00000113360 18550634,19633292,18548003,17540974,19398578 DICER1, ENSG00000100697 19229243,19843843 MYC, ENSG00000136997 18362916,18451220,19528081 DGCR8, ENSG00000128191 19398578 AKT, ENSG00000142208 19641183,18708351 CDKN1, ENSG00000124762 17991735 FOS, ENSG00000170345 18850008,19308091 NF-KB, ENSG00000173039 19072831,20144951,19997496 150977,MI0000780,mir-372 CDKN1, ENSG00000111276 18155131 MYC, ENSG00000136997 18451220 CDKN1, ENSG00000124762 18212054,19823043 151252,MI0003660,mir-645 DICER1, ENSG00000100697 16505370 150881,MI0000481,mir-184 BAD, ENSG00000002330 19033458 MYC, ENSG00000136997 18451220,17283129 151254,MI0003662,mir-647 DICER1, ENSG00000100697 16505370 150823,MI0000734,mir-106b CDKN1, ENSG00000111276 19153141 CASP9, ENSG00000132906 19096009 TP53, ENSG00000141510 19096009 PTEN, ENSG00000171862 19175831,19660235 MYC, ENSG00000136997 19096009,18922889 CDKN1, ENSG00000124762 19153141,18922889,18212054,19782699,19422085,19660235,18328430 MAPK14, ENSG00000112062 19559694 150903,MI0000737,mir-200a EGFR, ENSG00000146648 19671845 PTEN, ENSG00000171862 18199536 AKT, ENSG00000142208 18199536 150774,MI0000078,mir-22 MTOR, ENSG00000198793 20081105 PTEN, ENSG00000171862 20170724 MYC, ENSG00000136997 18066065,18314482 151172,MI0003570,mir-564 DICER1, ENSG00000100697 16505370 150904,MI0000342,mir-200b EGFR, ENSG00000146648 19671845 PTEN, ENSG00000171862 16762633 151081,MI0003154,mir-518f IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150771,MI0000076,mir-20a MEK, ENSG00000169032 15944709 EGFR, ENSG00000146648 19047896 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896 YWHAB, ENSG00000166913 15944709 PTEN, ENSG00000171862 19175831 RNASEN, ENSG00000113360 17558416 MYC, ENSG00000136997 18836483,15944709,18941111,18777135,18632605,19690137 CDKN1, ENSG00000124762 18941111,20089119 MAPK14, ENSG00000112062 19559694 NF-KB, ENSG00000173039 15944709 150917,MI0000291,mir-215 MDM2, ENSG00000135679 19074875 TP53, ENSG00000141510 19074876,19074875 CDKN1, ENSG00000124762 19074875 151009,MI0001723,mir-433 GRB2, ENSG00000177885 19531230 151262,MI0003677,mir-655 DICER1, ENSG00000100697 16505370 151012,MI0003673,mir-449b IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 19493678,18552348 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202 RNASEN, ENSG00000113360 19011087 DICER1, ENSG00000100697 16505370 MYC, ENSG00000136997 18802929,18314482,19530237 FOS, ENSG00000170345 16236258 151256,MI0003664,mir-649 DICER1, ENSG00000100697 16505370 150863,MI0000253,mir-148a MYC, ENSG00000136997 19435428,18768788 150916,MI0000290,mir-214 PTEN, ENSG00000171862 18199536 MYC, ENSG00000136997 19435428 AKT, ENSG00000142208 18199536 151170,MI0003568,mir-562 DICER1, ENSG00000100697 16505370 150844,MI0000474,mir-134 RNASEN, ENSG00000113360 19235467 MYC, ENSG00000136997 18451220 151160,MI0003575,mir-551b DICER1, ENSG00000100697 16505370 151232,MI0003640,mir-626 DICER1, ENSG00000100697 16505370 150888,MI0000465,mir-191 DICER1, ENSG00000100697 19906709 150857,MI0000460,mir-144 MAP3K8, ENSG00000107968 18006822 PTEN, ENSG00000171862 18704095 151215,MI0003622,mir-609 DICER1, ENSG00000100697 16505370 151216,MI0003623,mir-610 DICER1, ENSG00000100697 16505370 151123,MI0006344,mir-548e IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 20097187,19493678,18552348 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 18314482,18802929,19530237 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151171,MI0003569,mir-563 DICER1, ENSG00000100697 16505370 150772,MI0001519,mir-20b MEK, ENSG00000169032 15944709 YWHAB, ENSG00000166913 15944709 PTEN, ENSG00000171862 19175831 RNASEN, ENSG00000113360 19706389 MYC, ENSG00000136997 19706389,15944709,18777135 CDKN1, ENSG00000124762 18212054 NF-KB, ENSG00000173039 15944709 151227,MI0003635,mir-621 DICER1, ENSG00000100697 16505370 150760,MI0000267,mir-10b MEK, ENSG00000169032 17330104 EGFR, ENSG00000146648 19585508 151140,MI0006361,mir-548l IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 20097187,19493678,18552348 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 18314482,18802929,19530237 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150964,MI0000802,mir-340 PTEN, ENSG00000171862 19175831 151004,MI0001446,mir-424 ELK1, ENSG00000126767 20003307 EGFR, ENSG00000146648 17889671 CREB1, ENSG00000118260 20003307 150913,MI0000286,mir-210 EGFR, ENSG00000146648 19493678 MYC, ENSG00000136997 19652553 151251,MI0003659,mir-644 DICER1, ENSG00000100697 16505370 151218,MI0003625,mir-612 DICER1, ENSG00000100697 16505370 151177,MI0003577,mir-570 DICER1, ENSG00000100697 16505370 151027,MI0003530,mir-487b IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150744,MI0000064,let-7c MTOR, ENSG00000198793 20018759 MAP3K8, ENSG00000107968 18006822 CREB1, ENSG00000118260 19897480 PTEN, ENSG00000171862 16762633,18704095 MYC, ENSG00000136997 17438130,17877811,18006136,18802929 150920,MI0000293,mir-217 PTEN, ENSG00000171862 19543271 FOXO, ENSG00000150907 19786632 150849,MI0000454,mir-137 MYC, ENSG00000136997 18451220 150780,MI0000082,mir-25 CDKN1, ENSG00000111276 19153141 MKK4/7, ENSG00000065559 19861690 CDKN1, ENSG00000124762 19153141,18328430,19422085 150915,MI0000288,mir-212 MYC, ENSG00000136997 18314482 151244,MI0003653,mir-638 DICER1, ENSG00000100697 16505370 151239,MI0003648,mir-633 DICER1, ENSG00000100697 16505370 150872,MI0000681,mir-155 MAP3K8, ENSG00000107968 18006822 ERK, ENSG00000100030 19109256,19074725 IKK, ENSG00000104365 19650740 ELK1, ENSG00000126767 20003307 EGFR, ENSG00000146648 18668040 IKK, ENSG00000143466 19177201 CREB1, ENSG00000118260 20003307,19897480 JUN, ENSG00000177606 18668040,18940871 TP53, ENSG00000141510 17911264 PTEN, ENSG00000171862 19711427,19641183,19175697 RNASEN, ENSG00000113360 18550634 MYC, ENSG00000136997 18636108,18451220,18482561,19759154,17624268,18455451,16235244 AKT, ENSG00000142208 19699171,19641183 FOS, ENSG00000170345 18075594,18048365 NF-KB, ENSG00000173039 18940871 150861,MI0000262,mir-147 MYC, ENSG00000136997 18451220 150785,MI0000440,mir-27b RNASEN, ENSG00000113360 18550634,17540974 150941,MI0006418,mir-302f IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 20097187,19493678,18552348 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 18314482,18802929,19530237 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150960,MI0000816,mir-335 PIK3CA, ENSG00000121879 18185580 TP53, ENSG00000141510 18185580 AKT, ENSG00000142208 18185580 150806,MI0003560,mir-92b DICER1, ENSG00000100697 16505370 151141,MI0006400,mir-548m IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151179,MI0003579,mir-572 DICER1, ENSG00000100697 16505370 150905,MI0000650,mir-200c EGFR, ENSG00000146648 19671845 150775,MI0000079,mir-23a PTEN, ENSG00000171862 14697198,16762633 MYC, ENSG00000136997 20086171,19219026,19806017 MAPK14, ENSG00000112062 15131085 150907,MI0000283,mir-203 EGFR, ENSG00000146648 19047896 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896 DICER1, ENSG00000100697 18311128 151207,MI0003614,mir-601 DICER1, ENSG00000100697 16505370 151220,MI0003627,mir-614 DICER1, ENSG00000100697 16505370 150766,MI0000072,mir-18a MEK, ENSG00000169032 15944709 YWHAB, ENSG00000166913 15944709 PTEN, ENSG00000171862 19175831,18429962 RNASEN, ENSG00000113360 19706389,17558416 DICER1, ENSG00000100697 19416898 MYC, ENSG00000136997 19706389,18632605,19672269,15944709 FOS, ENSG00000170345 18445216 NF-KB, ENSG00000173039 15944709 151202,MI0003608,mir-596 DICER1, ENSG00000100697 16505370 151180,MI0003580,mir-573 DICER1, ENSG00000100697 16505370 151446,MI0006372,mir-1305 EGFR, ENSG00000146648 19493678 150843,MI0000822,mir-133b PTEN, ENSG00000171862 19175831 MYC, ENSG00000136997 18451220 151226,MI0003634,mir-620 DICER1, ENSG00000100697 16505370 151194,MI0003595,mir-587 DICER1, ENSG00000100697 16505370 151174,MI0003573,mir-567 DICER1, ENSG00000100697 16505370 151005,MI0001448,mir-425 DICER1, ENSG00000100697 19906709 151191,MI0003591,mir-584 DICER1, ENSG00000100697 16505370 151037,MI0003138,mir-497 CD28, ENSG00000178562 20148420 TP53, ENSG00000141510 18677302 PTEN, ENSG00000171862 19175831 151257,MI0003665,mir-650 DICER1, ENSG00000100697 16505370 150840,MI0000449,mir-132 MYC, ENSG00000136997 18451220 NF-KB, ENSG00000173039 19819989 150813,MI0000102,mir-100 MTOR, ENSG00000198793 18596100,20081105 PTEN, ENSG00000171862 18199536 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 19138993,19851984 MYC, ENSG00000136997 19372056,18451220 DGCR8, ENSG00000128191 19138993,19851984 AKT, ENSG00000142208 18199536 150800,MI0003646,mir-33b DICER1, ENSG00000100697 16505370 151196,MI0003599,mir-589 DICER1, ENSG00000100697 16505370 151217,MI0003624,mir-611 DICER1, ENSG00000100697 16505370 150980,MI0005566,mir-374b IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151231,MI0003639,mir-625 DICER1, ENSG00000100697 16505370 150825,MI0000442,mir-122 PTEN, ENSG00000171862 19711427 XPO5, ENSG00000124571 18025090 151198,MI0003603,mir-591 DICER1, ENSG00000100697 16505370 150768,MI0000073,mir-19a PTEN, ENSG00000171862 14697198,19175831,18460397,18429962 RNASEN, ENSG00000113360 17558416 MYC, ENSG00000136997 20008931,18632605 151295,MI0003906,mir-802 CREB1, ENSG00000118260 19897480 151032,MI0003131,mir-492 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 19138993,19851984 DGCR8, ENSG00000128191 19138993,19851984 151203,MI0003609,mir-597 DICER1, ENSG00000100697 16505370 151236,MI0003644,mir-630 CASP9, ENSG00000132906 20145152 DICER1, ENSG00000100697 16505370 151229,MI0003637,mir-623 DICER1, ENSG00000100697 16505370 150909,MI0000285,mir-205 PKC, ENSG00000171132 19244118 BAD, ENSG00000002330 19033458 PTEN, ENSG00000171862 20103531 151204,MI0003610,mir-598 DICER1, ENSG00000100697 16505370 151265,MI0003682,mir-658 PTEN, ENSG00000171862 19175831 DICER1, ENSG00000100697 16505370 151168,MI0003565,mir-559 DICER1, ENSG00000100697 16505370 151167,MI0003564,mir-558 DICER1, ENSG00000100697 16505370 150910,MI0000490,mir-206 EGFR, ENSG00000146648 19423651,18552348 CDKN1, ENSG00000111276 18155131 JUN, ENSG00000177606 19721712 TP53, ENSG00000141510 19626115,18552348 XPO5, ENSG00000124571 17008435 RNASEN, ENSG00000113360 19626115 FOS, ENSG00000170345 19721712 150880,MI0000273,mir-183 GRB2, ENSG00000177885 18511500 EGFR, ENSG00000146648 19047896,19493678 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896 DICER1, ENSG00000100697 19647520,19389351 CDKN1, ENSG00000124762 19782699 FOXO, ENSG00000150907 20028871 150792,MI0000441,mir-30b DICER1, ENSG00000100697 19416898 NF-KB, ENSG00000173039 20144951,19997496 150999,MI0003675,mir-411 DICER1, ENSG00000100697 16505370 151228,MI0003636,mir-622 DICER1, ENSG00000100697 16505370 151176,MI0003576,mir-569 DICER1, ENSG00000100697 16505370 150899,MI0000240,mir-198 EGFR, ENSG00000146648 18552348 TP53, ENSG00000141510 18552348 MYC, ENSG00000136997 18451220 151238,MI0003647,mir-632 DICER1, ENSG00000100697 16505370 151240,MI0003649,mir-634 DICER1, ENSG00000100697 16505370 150838,MI0000448,mir-130a PTEN, ENSG00000171862 14697198 RNASEN, ENSG00000113360 18550634 NF-KB, ENSG00000173039 20144951 151192,MI0003592,mir-585 DICER1, ENSG00000100697 16505370 150790,MI0000735,mir-29c CDC42, ENSG00000070831 19079265 TP53, ENSG00000141510 19347736,19158830 RNASEN, ENSG00000113360 17204650 150970,MI0000764,mir-363 ERK, ENSG00000100030 19074725 150879,MI0000272,mir-182 MTOR, ENSG00000198793 20081105 EGFR, ENSG00000146648 19493678 DICER1, ENSG00000100697 19416898 CDKN1, ENSG00000124762 19782699 FOXO, ENSG00000150907 20028871,19574223 FOXO, ENSG00000118689 19188590 151307,MI0005534,mir-891b IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 150858,MI0000461,mir-145 ELK1, ENSG00000126767 19578358 EGFR, ENSG00000146648 19493678,19047896,20097187 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896,19626115 PTEN, ENSG00000171862 19175697 RNASEN, ENSG00000113360 19626115 DICER1, ENSG00000100697 18776121 MYC, ENSG00000136997 19202062,19435428 CDKN1, ENSG00000124762 20089806 MAPK14, ENSG00000112062 15131085 151138,MI0006345,mir-548j IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 19493678,18552348,20097187 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 20080666,19672202 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151219,MI0003626,mir-613 DICER1, ENSG00000100697 16505370 151259,MI0003667,mir-652 DICER1, ENSG00000100697 16505370 150783,MI0000084,mir-26b PIK3CA, ENSG00000121879 19812400 TP53, ENSG00000141510 19812400 MYC, ENSG00000136997 18451220,18066065 151210,MI0003617,mir-604 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 16505370,19138993,19851984 DGCR8, ENSG00000128191 19138993,19851984 150978,MI0000781,mir-373 MKK4/7, ENSG00000065559 15685193 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 19138993,19851984 DGCR8, ENSG00000128191 19851984,19138993 MAPK14, ENSG00000112062 15685193 NF-KB, ENSG00000173039 15685193 150856,MI0000459,mir-143 ELK1, ENSG00000126767 19578358 CASP9, ENSG00000132906 19843160 TP53, ENSG00000141510 19626115 PTEN, ENSG00000171862 19175697 RNASEN, ENSG00000113360 19626115 MYC, ENSG00000136997 19435428 CDKN1, ENSG00000124762 20089806 150822,MI0000113,mir-106a EGFR, ENSG00000146648 19047896 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896,18521848 PTEN, ENSG00000171862 19175831 RNASEN, ENSG00000113360 19706389 MYC, ENSG00000136997 19706389,17943719 CDKN1, ENSG00000124762 18212054,20089119 150832,MI0000471,mir-126 CD28, ENSG00000178562 20148420 EGFR, ENSG00000146648 20097187,19493678 PIK3CA, ENSG00000121879 18185580 TP53, ENSG00000141510 18185580,18521848 RNASEN, ENSG00000113360 17540974,18550634 DICER1, ENSG00000100697 18776121 AKT, ENSG00000142208 18185580 151188,MI0003588,mir-581 DICER1, ENSG00000100697 16505370 151184,MI0003584,mir-577 DICER1, ENSG00000100697 16505370 150746,MI0000066,let-7e AKT, ENSG00000142208 19699171 MAPK14, ENSG00000112062 15131085 150918,MI0000292,mir-216a PTEN, ENSG00000171862 19543271 151169,MI0003567,mir-561 DICER1, ENSG00000100697 16505370 150824,MI0000114,mir-107 MYC, ENSG00000136997 18451220 DGCR8, ENSG00000128191 19440340 150967,MI0000826,mir-346 RNASEN, ENSG00000113360 19011087 150889,MI0000234,mir-192 MDM2, ENSG00000135679 19074875 EGFR, ENSG00000146648 19047896 PIK3CA, ENSG00000121879 19047896 TP53, ENSG00000141510 19047896,19074876,19074875 PTEN, ENSG00000171862 19543271 CDKN1, ENSG00000124762 19074875 151269,MI0003670,mir-662 DICER1, ENSG00000100697 16505370 151258,MI0003666,mir-651 DICER1, ENSG00000100697 16505370 150868,MI0000462,mir-152 FOXO, ENSG00000150907 20028871 151347,MI0006339,mir-1206 MYC, ENSG00000136997 18314482 151225,MI0003633,mir-619 DICER1, ENSG00000100697 16505370 151230,MI0003638,mir-624 DICER1, ENSG00000100697 16505370 150791,MI0000088,mir-30a XPO5, ENSG00000124571 19965479,19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 18776121,19138993,19851984 DGCR8, ENSG00000128191 19138993,19851984 151034,MI0003134,mir-494 PTEN, ENSG00000171862 20006626 151139,MI0006354,mir-548k IKK, ENSG00000104365 18408758 EGFR, ENSG00000146648 18552348,20097187,19493678 TP53, ENSG00000141510 18552348 PTEN, ENSG00000171862 19672202,20080666 RNASEN, ENSG00000113360 19011087 MYC, ENSG00000136997 19530237,18314482,18802929 CDKN1, ENSG00000124762 19890372 FOS, ENSG00000170345 16236258 151260,MI0003674,mir-653 DICER1, ENSG00000100697 16505370 151095,MI0003175,mir-520h MYC, ENSG00000136997 19435428 151029,MI0003124,mir-489 CDKN1, ENSG00000111276 18708351 PIK3CA, ENSG00000121879 18708351 TP53, ENSG00000141510 18708351 AKT, ENSG00000142208 18708351 150767,MI0001518,mir-18b MEK, ENSG00000169032 15944709 YWHAB, ENSG00000166913 15944709 PTEN, ENSG00000171862 19175831 MYC, ENSG00000136997 15944709 NF-KB, ENSG00000173039 15944709 151235,MI0003643,mir-629 DICER1, ENSG00000100697 16505370 151186,MI0003586,mir-579 DICER1, ENSG00000100697 16505370 151263,MI0003678,mir-656 DICER1, ENSG00000100697 16505370 151201,MI0003607,mir-595 DICER1, ENSG00000100697 16505370 151241,MI0003650,mir-635 DICER1, ENSG00000100697 16505370 151214,MI0003621,mir-608 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 19138993,19851984,16505370 DGCR8, ENSG00000128191 19138993,19851984 151270,MI0003672,mir-663 DICER1, ENSG00000100697 16505370 150787,MI0000087,mir-29a CDC42, ENSG00000070831 19079265 TP53, ENSG00000141510 19347736 RNASEN, ENSG00000113360 17204650,19560422 MYC, ENSG00000136997 18066065 FOS, ENSG00000170345 16236258 FOXO, ENSG00000150907 20028871 NF-KB, ENSG00000173039 20144951 151190,MI0003590,mir-583 DICER1, ENSG00000100697 16505370 150854,MI0000457,mir-141 MKK4/7, ENSG00000065559 19861690 PTEN, ENSG00000171862 16762633,20053927 MYC, ENSG00000136997 20053927 MAPK14, ENSG00000112062 15131085 151267,MI0003684,mir-660 DICER1, ENSG00000100697 16505370 151247,MI0003656,mir-641 DICER1, ENSG00000100697 16505370 151161,MI0003557,mir-552 DICER1, ENSG00000100697 16505370 151193,MI0003594,mir-586 DICER1, ENSG00000100697 16505370 150801,MI0000268,mir-34a MTOR, ENSG00000198793 20018759 ERK, ENSG00000100030 19006648 MDM2, ENSG00000135679 20089965,18451145,19074875,18677110,18711402 PIK3R1, ENSG00000145675 14744438 ELK1, ENSG00000126767 19696787 EGFR, ENSG00000146648 19890883 RPS6KA5, ENSG00000100784 14744438 CAMK, ENSG00000058404 14744438 TP53, ENSG00000141510 19643983,19098429,18941118,19584398,19074876,17875987,19383911,18818704,17554337,18451145,18803879,19074875,19221490,19347736,17554199,19158830,17540599,17540598 PTEN, ENSG00000171862 16762633,18704095,14697198,14744438 PKC, ENSG00000163932 14744438 PDPK1, ENSG00000140992 14744438 MYC, ENSG00000136997 19696787,18823940,19211792,18066065 CDKN1, ENSG00000124762 19643983,19074875,18677110 151178,MI0003578,mir-571 DICER1, ENSG00000100697 16505370 150925,MI0000298,mir-221 MTOR, ENSG00000198793 20018759 ERK, ENSG00000100030 19438724 CDKN1, ENSG00000111276 19264608,18521080,19150885,17569667,18417445,19749093,19107213,17627278,19671867,18155131,18708351,19088079,19153141,17914108,19424584,17721077,19126397,19273599,19767219,18413744 PIK3CA, ENSG00000121879 18708351,18790736 TP53, ENSG00000141510 18708351,18790736 PTEN, ENSG00000171862 19730150,19711427,18704095,19962668,20021821 RNASEN, ENSG00000113360 18550634,17540974 MYC, ENSG00000136997 17943719 AKT, ENSG00000142208 18708351,18790736 CDKN1, ENSG00000124762 19153141 151164,MI0003561,mir-555 DICER1, ENSG00000100697 16505370 150859,MI0000477,mir-146a ELK1, ENSG00000126767 19696787 EGFR, ENSG00000146648 19585508,20124483 XPO5, ENSG00000124571 19138993 TARBP2, ENSG00000139546 19138993 RNASEN, ENSG00000113360 19138993 DICER1, ENSG00000100697 19138993 MYC, ENSG00000136997 18066065,19696787 DGCR8, ENSG00000128191 19138993