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Sulav Duwal, Laura Dickinson, Saye Khoo, Max von Kleist
Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes
www.ploscompbiol.org
www.ploscompbiol.org
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3.719 0 Td
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q
1 j
1 J
0 w
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BT
/F2 1 Tf
1 TL
-0.0033 Tc
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ET
Q
q
1 j
1 J
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(13)Tj
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(16)Tj
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[()-3()1()4(\r)11()]TJ
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(17)Tj
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1.7348 0 Td
(18)Tj
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([)Tj
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(19)Tj
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3.2825 0 Td
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1.9842 0 Td
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(cells,)Tj
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(it)Tj
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(cell)Tj
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(which)Tj
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(a)Tj
0.6519 0 Td
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(shift)Tj
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(the)Tj
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(these)Tj
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(clearance.)Tj
4.1726 0 Td
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4.2349 0 Td
(dynamics)Tj
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(this)Tj
1.6725 0 Td
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(a)Tj
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(multivariate)Tj
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(Poisson)Tj
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1.7802 0 Td
(evolution)Tj
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(of)Tj
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(the)Tj
1.4683 0 Td
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(given)Tj
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(the)Tj
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(ini-)Tj
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(tial)Tj
1.4626 0 Td
(state)Tj
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2.0353 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 239.6409 235.7291 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 245.4236 237.3732 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(is)Tj
0.8447 0 Td
(then)Tj
2.0182 0 Td
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(\(CME\).)Tj
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2.0295 0 Td
(possible)Tj
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(state)Tj
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2.0352 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 573.7322 235.7291 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 224.3905 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(we)Tj
1.3266 0 Td
(have)Tj
ET
Q
q
1 j
1 J
0 w
249.5055 198.5953 m
257.8961 198.5953 l
257.8961 198.1984 l
249.5055 198.1984 l
f*
10 0 0 10 251.0362 202.6771 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
-0.153 -1.3662 Td
[()14()]TJ
/F12 1 Tf
1.009 0.6859 Td
( 3)Tj
/F13 1 Tf
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 275.8677 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 281.1968 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 296.3905 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 298.4881 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(j)Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 307.559 193.3795 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 313.8519 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 329.0456 193.3795 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 332.5039 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
1.5533 0 Td
()Tj
/F15 1 Tf
1.7745 0.9467 Td
(X)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 370.7716 207.3259 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
-0.5102 -3.6568 Td
[()]TJ
/F13 1 Tf
()Tj
/F14 1 Tf
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 380.1259 195.874 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[(\r)]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 385.0015 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 388.3464 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 396.907 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 401.2157 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
( )Tj
/F16 1 Tf
0.9977 0 Td
(n)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 415.559 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 418.8472 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
0.6066 0 Td
()Tj
/F12 1 Tf
0.4932 0 Td
( 3)Tj
/F13 1 Tf
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 446.1165 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 451.4456 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 466.6393 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 470.948 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
( )Tj
/F16 1 Tf
0.9977 0 Td
(n)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 485.2913 193.3795 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.5795 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(j)Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 497.6503 193.3795 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 503.9433 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 519.137 193.3795 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 522.6519 195.874 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
-15.6868 -2.5001 Td
( )Tj
/F11 1 Tf
0.771 0 Td
[(\r)]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 378.3685 168.3779 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 381.7133 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 390.2173 168.3779 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 392.3716 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
/F12 1 Tf
0.4932 0 Td
( 3)Tj
/F13 1 Tf
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 419.5842 168.3779 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 424.9133 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0544 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 440.107 168.3779 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 442.2614 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(j)Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 451.3322 168.3779 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 457.6251 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 472.7622 168.3779 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 476.2771 170.8724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
/F10 1 Tf
(;)Tj
/F6 1 Tf
-0.004 Tc
-27.6262 -2.279 Td
(for)Tj
1.3833 0 Td
(time)Tj
/F11 1 Tf
2.0296 0 Td
[()]TJ
/F13 1 Tf
0 Tc
0.5215 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9865 0 Td
(0,)Tj
0.9241 0 Td
(with)Tj
/F11 1 Tf
0 Tc
1.9955 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 284.7685 145.5874 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 290.1543 148.0818 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(2)Tj
/F12 1 Tf
0.9297 0 Td
( 1)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 306.6519 152.5039 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 311.3574 148.0818 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(denoting)Tj
3.8097 0 Td
(the)Tj
1.4683 0 Td
(state)Tj
2.0353 0 Td
(of)Tj
1.0148 0 Td
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