%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Petra Gehle, Barbara Goergen, Daniel Pilger, Peter Ruokonen, Peter N. Robinson, Daniel J. Salchow
Biometric and structural ocular manifestations of Marfan syndrome
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 15 0 R/Contents 16 0 R/TrimBox[0 0 612 792]>>
endobj
15 0 obj
[17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref001)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref002)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref003)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref004)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref005)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref006)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref007)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref007)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref008)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref010)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183370.ref006)>>
endobj
29 0 obj
<>/Border[0 0 0]/A 30 0 R>>
endobj
30 0 obj
<>
endobj
16 0 obj
[31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R]
endobj
31 0 obj
<>stream
q
0.83 0.64 0.02 0 k
364.1386 674.9858 m
368.9008 674.9858 l
h
f*
373.3795 674.9858 m
378.085 674.9858 l
h
f*
340.4409 662.0031 m
345.2031 662.0031 l
h
f*
203.4142 635.9811 m
208.1764 635.9811 l
h
f*
452.5795 635.9811 m
457.3417 635.9811 l
h
f*
466.526 610.0157 m
471.2882 610.0157 l
h
f*
256.7055 532.0063 m
261.4677 532.0063 l
h
f*
266.6268 532.0063 m
276.1512 532.0063 l
h
f*
229.5496 519.0236 m
234.3118 519.0236 l
h
f*
238.7339 519.0236 m
243.4961 519.0236 l
h
f*
247.9748 519.0236 m
257.4992 519.0236 l
h
f*
458.8157 264.926 m
463.5213 264.926 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Marfan)Tj
3.1861 0 Td
(syndrome)Tj
4.2349 0 Td
(\(MFS\),)Tj
3.0217 0 Td
(an)Tj
1.2019 0 Td
(autosomal)Tj
4.354 0 Td
(dominant)Tj
4.1726 0 Td
(connective)Tj
4.5354 0 Td
(tissue)Tj
2.4604 0 Td
(disorder,)Tj
3.8041 0 Td
(is)Tj
0.8447 0 Td
(caused)Tj
2.9197 0 Td
(by)Tj
-34.7355 -1.3039 Td
(mutations)Tj
4.2802 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(fibrillin-1)Tj
4.0536 0 Td
(gene)Tj
2.0806 0 Td
(\()Tj
/F10 1 Tf
[()]TJ
/F6 1 Tf
(\).[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.4163 0 Td
(2)Tj
0 g
(])Tj
1.0318 0 Td
(Fibrillin-1)Tj
4.2973 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6576 0 Td
(major)Tj
2.6078 0 Td
(constituent)Tj
4.7225 0 Td
(of)Tj
1.0148 0 Td
(microfibrils,)Tj
-32.5131 -1.2982 Td
(involved)Tj
3.651 0 Td
(in)Tj
1.0318 0 Td
(elastic)Tj
2.6758 0 Td
(fiber)Tj
2.075 0 Td
(formation.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
5.6409 0 Td
(Manifestations)Tj
6.1511 0 Td
(of)Tj
1.0148 0 Td
(MFS)Tj
2.1147 0 Td
(affect)Tj
2.3754 0 Td
(multiple)Tj
3.566 0 Td
(organ)Tj
2.5454 0 Td
(systems)Tj
-32.8419 -1.2983 Td
(including)Tj
4.0421 0 Td
(skeletal)Tj
3.1465 0 Td
(muscle,)Tj
3.2484 0 Td
(skin,)Tj
2.1204 0 Td
(the)Tj
1.4683 0 Td
(cardiovascular)Tj
6.0037 0 Td
(system)Tj
2.9367 0 Td
(\(e.g.)Tj
1.8992 0 Td
(aortic)Tj
2.5228 0 Td
(dissection\))Tj
4.5411 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(eye.)Tj
-35.1323 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(])Tj
1.3719 0 Td
(Up)Tj
1.474 0 Td
(to)Tj
1.0262 0 Td
(54%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(MFS)Tj
2.1203 0 Td
(patients)Tj
3.3675 0 Td
(have)Tj
2.058 0 Td
(major)Tj
2.6078 0 Td
(ocular)Tj
2.7326 0 Td
(involvement,[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
6.5934 0 Td
(and)Tj
1.7291 0 Td
(ocular)Tj
2.7269 0 Td
(findings)Tj
3.4923 0 Td
(may)Tj
1.9332 0 Td
(be)Tj
-36.1755 -1.2983 Td
(crucial)Tj
2.9139 0 Td
(in)Tj
1.0319 0 Td
(establishing)Tj
4.9265 0 Td
(the)Tj
1.474 0 Td
(diagnosis.)Tj
-9.1501 -1.2982 Td
(Diagnostic)Tj
4.5297 0 Td
(criteria)Tj
3.0784 0 Td
(were)Tj
2.1203 0 Td
(last)Tj
1.5591 0 Td
(updated)Tj
3.4752 0 Td
(in)Tj
1.0375 0 Td
(2010)Tj
2.1203 0 Td
(\(Ghent)Tj
3.0784 0 Td
(2)Tj
0.6916 0 Td
(criteria\).[)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
4.8019 0 Td
(In)Tj
1.1055 0 Td
(these)Tj
2.2564 0 Td
(criteria,)Tj
3.2995 0 Td
(ectopia)Tj
-34.35 -1.304 Td
(lentis)Tj
2.364 0 Td
(\(EL\))Tj
2.0069 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(cardinal)Tj
3.4696 0 Td
(diagnostic)Tj
4.32 0 Td
(feature.)Tj
3.2144 0 Td
(Other)Tj
2.5852 0 Td
(diagnostic)Tj
4.32 0 Td
(ocular)Tj
2.7326 0 Td
(findings)Tj
3.4922 0 Td
(are)Tj
1.4457 0 Td
(down-slanting)Tj
-31.453 -1.2982 Td
(palpebral)Tj
3.9174 0 Td
(fissures,)Tj
3.4016 0 Td
(enophthalmos)Tj
5.9413 0 Td
(and)Tj
1.7292 0 Td
(myopia)Tj
/F11 1 Tf
0 Tc
3.2201 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(3)Tj
0.6917 0 Td
(diopters)Tj
3.4979 0 Td
(\(D\).)Tj
1.8595 0 Td
(Increased)Tj
4.0762 0 Td
(axial)Tj
2.0636 0 Td
(length)Tj
2.7269 0 Td
(\()Tj
/F12 1 Tf
0 Tc
(>)Tj
/F6 1 Tf
-0.004 Tc
1.3323 0 Td
(23.5)Tj
-35.4498 -1.2983 Td
(mm\),)Tj
2.4207 0 Td
(flat)Tj
1.491 0 Td
(cornea)Tj
2.9254 0 Td
(\()Tj
/F12 1 Tf
0 Tc
(<)Tj
/F6 1 Tf
-0.004 Tc
1.3322 0 Td
(41.5)Tj
1.8709 0 Td
(D)Tj
0.9581 0 Td
(average)Tj
3.2258 0 Td
(corneal)Tj
3.1748 0 Td
(curvature\),)Tj
4.6148 0 Td
(iris)Tj
1.491 0 Td
(transillumination)Tj
7.2056 0 Td
(defects)Tj
2.9707 0 Td
(\(ITD\))Tj
-33.681 -1.2983 Td
(and)Tj
1.7291 0 Td
(retinal)Tj
2.8063 0 Td
(detachment)Tj
4.9492 0 Td
(\(RD\))Tj
2.2564 0 Td
(are)Tj
1.4513 0 Td
(common)Tj
3.8438 0 Td
(in)Tj
1.0374 0 Td
(MFS)Tj
2.1147 0 Td
(but)Tj
1.5533 0 Td
(not)Tj
1.5704 0 Td
(part)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Ghent)Tj
2.7326 0 Td
(2)Tj
0.6973 0 Td
(criteria.)Tj
-29.8713 -1.3039 Td
(Although)Tj
4.0081 0 Td
(descriptive)Tj
4.5524 0 Td
(studies)Tj
2.9877 0 Td
(on)Tj
1.2756 0 Td
(ocular)Tj
2.7269 0 Td
(manifestations)Tj
6.0775 0 Td
(of)Tj
1.0148 0 Td
(MFS)Tj
2.1146 0 Td
(are)Tj
1.4513 0 Td
(available,)Tj
3.8891 0 Td
(most)Tj
2.2111 0 Td
(are)Tj
-33.5053 -1.2982 Td
(smaller)Tj
3.118 0 Td
(series[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(])Tj
5.057 0 Td
(focusing)Tj
3.6057 0 Td
(on)Tj
1.2755 0 Td
(biometric)Tj
4.1046 0 Td
(or)Tj
1.0998 0 Td
(structural)Tj
4.0762 0 Td
(findings)Tj
3.4923 0 Td
(without)Tj
3.3335 0 Td
(including)Tj
4.0422 0 Td
(a)Tj
0.6519 0 Td
(control)Tj
-33.8567 -1.2983 Td
(group.[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
3.8721 0 Td
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.924 0 Td
(10)Tj
0 g
(])Tj
-3.5999 -1.3039 Td
(To)Tj
1.3379 0 Td
(better)Tj
2.5455 0 Td
(define)Tj
2.6986 0 Td
(the)Tj
1.4683 0 Td
(ocular)Tj
2.7326 0 Td
(manifestations)Tj
6.0718 0 Td
(of)Tj
1.0148 0 Td
(MFS)Tj
2.1146 0 Td
(and)Tj
1.7348 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3868 0 Td
(which)Tj
2.6532 0 Td
(parameters)Tj
4.6715 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(of)Tj
-36.7311 -1.2983 Td
(diagnostic)Tj
4.3199 0 Td
(value,)Tj
2.5285 0 Td
(we)Tj
1.3266 0 Td
(analyzed)Tj
3.702 0 Td
(ocular)Tj
2.7326 0 Td
(biometric)Tj
4.1046 0 Td
(and)Tj
1.7291 0 Td
(structural)Tj
4.0818 0 Td
(findings)Tj
3.4923 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(large)Tj
2.16 0 Td
(cohort)Tj
2.8517 0 Td
(of)Tj
-34.7185 -1.2982 Td
(MFS)Tj
2.1146 0 Td
(patients)Tj
3.3675 0 Td
(and)Tj
1.7291 0 Td
(compared)Tj
4.2463 0 Td
(them)Tj
2.2904 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(control)Tj
3.1238 0 Td
(group.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 445.0393 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.4976 Td
(Study)Tj
2.7543 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 410.0598 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Records)Tj
3.4525 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(presenting)Tj
4.4447 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(interdisciplinary)Tj
6.8145 0 Td
(Marfan)Tj
3.1918 0 Td
(clinic)Tj
2.3924 0 Td
(at)Tj
0.9524 0 Td
(Charite)Tj
0 Tc
2.5852 0.051 Td
()Tj
-0.004 Tc
0.4025 -0.051 Td
(-Unversity)Tj
-31.1128 -1.2982 Td
(Medicine)Tj
3.9911 0 Td
(Berlin)Tj
2.6589 0 Td
(over)Tj
1.9729 0 Td
(a)Tj
0.6576 0 Td
(period)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(four)Tj
1.9106 0 Td
(years)Tj
2.2677 0 Td
(\(December)Tj
4.6885 0 Td
(2009)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(December)Tj
4.3483 0 Td
(2013\))Tj
2.4605 0 Td
(were)Tj
-31.9519 -1.3039 Td
(reviewed.)Tj
4.0195 0 Td
(The)Tj
1.7801 0 Td
(institutional)Tj
5.091 0 Td
(review)Tj
2.846 0 Td
(board)Tj
2.5681 0 Td
(approved)Tj
3.9685 0 Td
(the)Tj
1.474 0 Td
(study)Tj
2.3868 0 Td
(and)Tj
1.7291 0 Td
(waived)Tj
3.0104 0 Td
(the)Tj
1.474 0 Td
(need)Tj
2.143 0 Td
(for)Tj
1.3833 0 Td
(study)Tj
-33.8738 -1.2983 Td
(subjects)Tj
3.3788 0 Td
(to)Tj
1.0262 0 Td
(consent)Tj
3.3278 0 Td
(for)Tj
1.389 0 Td
(their)Tj
2.1033 0 Td
(records)Tj
3.2088 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
1.0375 0 Td
(this)Tj
1.6724 0 Td
(study.)Tj
2.6135 0 Td
(The)Tj
1.7802 0 Td
(data)Tj
1.9162 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(and)Tj
1.7291 0 Td
(ana-)Tj
-35.2797 -1.2983 Td
(lyzed)Tj
2.2847 0 Td
(anonymously.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 322.0157 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Diagnosis)Tj
4.5496 0 Td
(of)Tj
1.0441 0 Td
(Marfan)Tj
3.3024 0 Td
(syndrome)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 305.0078 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(complete)Tj
3.8777 0 Td
(medical)Tj
3.3562 0 Td
(and)Tj
1.7292 0 Td
(family)Tj
2.7269 0 Td
(history)Tj
3.0047 0 Td
(was)Tj
1.6951 0 Td
(obtained.)Tj
3.9571 0 Td
(Patients)Tj
3.4072 0 Td
(received)Tj
3.532 0 Td
(a)Tj
0.652 0 Td
(skeletal)Tj
3.1464 0 Td
(exam,)Tj
2.5852 0 Td
(a)Tj
0.6519 0 Td
(cardi-)Tj
-35.223 -1.2982 Td
(ologic)Tj
2.6362 0 Td
(evaluation)Tj
4.3596 0 Td
(including)Tj
4.0422 0 Td
(a)Tj
0.652 0 Td
(trans-thoracic)Tj
5.8393 0 Td
(echocardiogram,)Tj
6.9448 0 Td
(a)Tj
0.652 0 Td
(genetic)Tj
3.0727 0 Td
(analysis)Tj
3.3279 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(complete)Tj
-33.9078 -1.2983 Td
(ophthalmologic)Tj
6.5139 0 Td
(exam.)Tj
-5.3177 -1.3039 Td
(MFS)Tj
2.1203 0 Td
(was)Tj
1.6951 0 Td
(diagnosed)Tj
4.2859 0 Td
(according)Tj
4.1839 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(revised)Tj
3.0501 0 Td
(Ghent)Tj
2.7326 0 Td
(2)Tj
0.6973 0 Td
(criteria.[)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
4.456 0 Td
(Patients)Tj
3.4129 0 Td
(with)Tj
1.9956 0 Td
(MFS)Tj
2.1146 0 Td
(were)Tj
-34.435 -1.2983 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3924 0 Td
(group,)Tj
2.8346 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6577 0 Td
(connective)Tj
4.5354 0 Td
(tissue)Tj
2.4604 0 Td
(disorder)Tj
3.5773 0 Td
(other)Tj
2.3471 0 Td
(than)Tj
2.0296 0 Td
(MFS)Tj
2.1146 0 Td
(were)Tj
-34.5257 -1.2982 Td
(excluded.)Tj
4.0081 0 Td
(Patients)Tj
3.4129 0 Td
(without)Tj
3.3279 0 Td
(MFS)Tj
2.1146 0 Td
(and)Tj
1.7348 0 Td
(other)Tj
2.3471 0 Td
(hereditary)Tj
4.3199 0 Td
(connective)Tj
4.5354 0 Td
(tissue)Tj
2.4605 0 Td
(disorders)Tj
3.9345 0 Td
(were)Tj
-32.1957 -1.3039 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(control)Tj
3.1237 0 Td
(group.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 190.9984 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ophthalmological)Tj
7.8473 0 Td
(examination)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 173.9905 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Best-corrected)Tj
6.0037 0 Td
(visual)Tj
2.5058 0 Td
(acuity,)Tj
2.8516 0 Td
(objective)Tj
3.7814 0 Td
(refraction)Tj
4.1556 0 Td
(\(Humphrey)Tj
4.9663 0 Td
(Automatic)Tj
4.4843 0 Td
(Refractor)Tj
3.9572 0 Td
(599,)Tj
1.8708 0 Td
(Carl)Tj
-34.5767 -1.2982 Td
(Zeiss)Tj
2.2336 0 Td
(Meditec)Tj
3.4753 0 Td
(Inc.,)Tj
1.9842 0 Td
(Dublin,)Tj
3.2769 0 Td
(CA,)Tj
1.7914 0 Td
(USA\),)Tj
2.6816 0 Td
(and)Tj
1.7291 0 Td
(manifest)Tj
3.6624 0 Td
(refraction)Tj
4.1499 0 Td
(\(if)Tj
1.1168 0 Td
(necessary\))Tj
4.3597 0 Td
(were)Tj
2.1259 0 Td
(measured.)Tj
-32.5868 -1.2983 Td
(Intraocular)Tj
4.7224 0 Td
(pressure)Tj
3.5773 0 Td
(\(IOP\))Tj
2.5455 0 Td
(was)Tj
1.6951 0 Td
(measured)Tj
4.1103 0 Td
(with)Tj
1.9955 0 Td
(non-contact)Tj
5.108 0 Td
(tonometry)Tj
4.4504 0 Td
(\(NCT,)Tj
2.7949 0 Td
(Nidek)Tj
2.6703 0 Td
(NT-530,)Tj
-33.6697 -1.3039 Td
(Nidek)Tj
2.6702 0 Td
(Co.)Tj
1.6157 0 Td
(Ltd.,)Tj
2.0353 0 Td
(Aichi,)Tj
2.6135 0 Td
(Japan\),)Tj
3.0501 0 Td
(and)Tj
1.7291 0 Td
(confirmed)Tj
4.3993 0 Td
(with)Tj
1.9956 0 Td
(Goldmann)Tj
4.5638 0 Td
(applanation)Tj
4.9776 0 Td
(tonometry)Tj
4.4447 0 Td
(if)Tj
0.7766 0 Td
(NCT)Tj
-34.8715 -1.2983 Td
(was)Tj
1.6951 0 Td
(unreliable)Tj
4.2179 0 Td
(or)Tj
1.0998 0 Td
(outside)Tj
3.1294 0 Td
(the)Tj
1.4684 0 Td
(normal)Tj
3.1464 0 Td
(range.)Tj
2.6929 0 Td
(A)Tj
0.9014 0 Td
(slitlamp)Tj
3.4129 0 Td
(exam)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(anterior)Tj
3.4412 0 Td
(segment)Tj
3.5603 0 Td
(was)Tj
1.7008 0 Td
(done)Tj
-35.3081 -1.2982 Td
(before)Tj
2.7382 0 Td
(and)Tj
1.7291 0 Td
(after)Tj
2.0353 0 Td
(pupil)Tj
2.296 0 Td
(dilation.)Tj
3.5433 0 Td
(EL)Tj
1.3266 0 Td
(was)Tj
1.7008 0 Td
(diagnosed)Tj
4.2803 0 Td
(if)Tj
0.7767 0 Td
(the)Tj
1.4683 0 Td
(edge)Tj
2.058 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(lens)Tj
1.8028 0 Td
(was)Tj
1.7008 0 Td
(visible)Tj
2.7439 0 Td
(after)Tj
2.0353 0 Td
(pupil)Tj
-34.7185 -1.3039 Td
(dilation)Tj
3.3165 0 Td
(pupil)Tj
2.296 0 Td
(\(with)Tj
2.3357 0 Td
(neosynephrine)Tj
6.1399 0 Td
(2.5%)Tj
2.1543 0 Td
(and)Tj
1.7291 0 Td
(tropicamide)Tj
5.0796 0 Td
(1%)Tj
1.4514 0 Td
(eye)Tj
1.525 0 Td
(drops\).)Tj
3.0671 0 Td
(Dilated)Tj
3.1521 0 Td
(fundus)Tj
-32.2467 -1.2983 Td
(examination)Tj
5.2327 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.473 0 Td
(using)Tj
2.3868 0 Td
(indirect)Tj
3.3505 0 Td
(ophthalmoloscopy.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 439.4834 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Eye)Tj
1.9204 0 Td
(manifesta)Tj
4.2591 0 Td
(tions)Tj
2.2961 0 Td
(in)Tj
0.978 0 Td
(Marfan)Tj
3.2882 0 Td
(syndrom)Tj
3.7701 0 Td
(e)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01833)Tj
4.089 0 Td
(70)Tj
0 g
2.0906 0 Td
(September)Tj
5.0386 0 Td
(20,)Tj
1.5874 0 Td
(2017)Tj
32.2798 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F7 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F8 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
BT
10.3394 82.7156 Td
(exist.)Tj
ET
Q
endstream
endobj
46 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 52 0 R/Contents 53 0 R/TrimBox[0 0 612 792]>>
endobj
49 0 obj
<>
endobj
54 0 obj
<>
endobj
55 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /PI_chars_3 def
/FontType 1 def
/FontBBox {-11 -345 1373 718} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (PI_chars_3) readonly def
/BaseFontName (PI_chars_3) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 58 /colon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤/{zM4aܪ
Q:д'B-r^ܦ6y?rRnu S\U{Oλrs(Βƚ
#d29%s'ƈT1F8&\0Xd&&Zug'VPd]:>u=Q,?#(CV4'..|ӱ5 h
sȀg)fɘ`UXK^>] q\l#5pE"JO}rquáQBr/E7
QW5\GSlu{7ZH(PSf/O;̟w{ɴ}-K hA8!b!U>`#u?Vlnǝ19V+mg'QmA}S Y$í8n uJ ڒx3>[x0Z]
ͩw4M&1+pkC,sr"%q&OjbH{:5$65*S`cr;%s4Oӆe>T+6~pBOD!$c]"~r#nh6$38i˞[~Z}}rHmte9(1½=j{<\ ;? RA?c{Rf1'VԞ_-Lwo]`.l|zjf"![G1BYro˓9[-+z g!}RN+pX!M~HcFh@g%J6B)6!Lq>TX\ݪGF
PiQݓX~Fs;Ölo4/(C?+,ɖxۼ:xU^)
fd,`*>-:}=q$:\Xzcw1Nf(
ZkEeJXfэi@zXc\{a5qKg\5ݩv\Qe%1>OY̗$Y#P[)."^+{"bP]Bt&zeN6
іijDE% 0;̅
~~lfB>u'i4znym%tfԟ^נBTDS6-ghiWk/(r!!˶fc>趕%U